TripleNegative Ten Point Plan

We felt the most important thing was to get the best possible advice. This isn’t as easy as it seems and you speak to a lot of different people before you feel comfortable with the right balance of shared mind set, experience and availability. We’ve selected the following professional consultant’s on the criteria above but sadly we know that other factors may come into effect such as financial resource, ability to travel and your personal feelings.

Professor Angus Dalgleish Professor of Oncology, Research centre: Infection and Immunity. Research interests are HIV, pathogenesis, therapeutic vaccines, cancer vaccines, immunomodulatory drugs, Thalidomide analogues, melanoma, prostate, pancreatic cancers. His main research interests include the pathogenesis of HIV infection and development of a therapeutic vaccine. His second main area of interest has been the development of Thalidomide for use in chronic infectious diseases and cancer. Working with Celgene from the beginning of this programme, a number of analogues have been shown to be extremely effective anti cancer agents; Revlimid is licensed worldwide for the treatment of myeloma. Ongoing interest in these analogues is focusing on their ability to synergise with other agents, such as Gemcitabine, as well as enhance the affect of vaccination. In addition to Revlimid, new analogues are now available for laboratory and clinical trials. His third major research interest is the development of therapeutic cancer vaccines. In addition to basic clinical work he has been involved in trials with melanoma, prostate and pancreatic cancer. Current focus is the interaction of other modalities, such as radiotherapy and chemotherapy, with these vaccines.

Appointed to Foundation Chair of Oncology, St. George’s, 1991.

Graduated from University College London with an intercalated BSc in Anatomy. Following registration, trained in general medicine and oncology in Brisbane and Sydney.

Undertook a PhD with Robin Weiss, ICR, before becoming a senior clinical scientist at the MRC Clinical Research Centre, Northwick Park.

He is a member of numerous editorial boards, research committees, grant committees and was, until 2009, Chairman of the Rare Sub Group of NCRN Melanoma Group and currently President, Royal Society of Medicine Clinical Immunology Section until 2011. He has published over 300 peer reviewed papers, co-edited 5 text books. I served/serve on numerous grant committees, including AMRF (U.S.A), Genome Canada, EU Framework, and ongoing research programmes in Belgium and Austria. He is a visiting examiner, Nottingham University, and external lecturer, Karolinska Institute.

Professor Adrian L Harris is the Cancer Research UK Professor of Medical Oncology at the University of Oxford and directs the Cancer Research UK Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine. He is Director of the Cancer Research UK Medical Oncology Unit at the Churchill Hospital, a Consultant Medical Oncologist, and a Professorial Fellow of St Hugh’s College Oxford. He is Head of the CRUK Oxford Cancer Centre and the Oxford Experimental Cancer Medicine Centre. He is Editor-in-Chief of the British Journal of Cancer.

Professor Harris trained in Medicine and Biochemistry at Liverpool University, did a DPhil at Oxford University then trained at the Royal Marsden Hospital in Medical Oncology. He was appointed Professor of Clinical Oncology at Newcastle-upon-Tyne in 1982. Since 1988 he has been the Professor of Medical Oncology at Oxford University.

His major laboratory interests involve the role of hypoxia in tumour biology and angiogenesis; and new drug development. He is investigating the roles of hypoxia and Notch signalling in angiogenesis, micro RNAs induced by hypoxia and hypoxia induced cell death. He specialises in breast cancer and has previously treated a wide range of tumour types including urological cancers, lung cancer, gynaecological cancers and haematological malignancy. He has published over 800 scientific papers and reviews.

Professor Justin Stebbing trained in medicine at Trinity College Oxford, where he gained a triple first class degree. After completion of junior doctor posts in Oxford, he undertook a residency at The Johns Hopkins Hospital in the US, returning to London to continue his training in oncology at The Royal Marsden and St Bartholomew’s Hospitals. Professor Stebbing’s PhD research investigated the interplay between the immune system and cancer.

Professor Stebbing has published over 400 peer-reviewed papers in journals such as the Lancet, New England Journal, Blood, the Journal of Clinical Oncology, Annals of Internal Medicine, as well as writing for national newspapers and presenting new data on optimal cancer therapies at major international conferences. His focus is on new therapies in cancer, and the systemic management of patients with a variety of solid malignancies.

He is a member of the Royal College of Physicians, the American Board of Internal Medicine and the Royal College of Pathologists, and sits on the advisory Boards of five biotechnology companies. He chairs the World Vaccine Congress and is on the editorial board of a number of world leading general medical and cancer journals such as the Journal of Clinical Oncology and Oncogene. In 2011 Justin’s team discovered a new cancer gene, work that has been published in Nature Medicine. In 2012, the National Institute for Health Research awarded Justin Stebbing its first research translational professorship in cancer medicine, aiming to turn developments in the laboratory into better and more tailored personalised treatments for patients.

Dr Stephen Ray – Dendritic cell therapy Steve is a neuroscientist holding a faculty position at Oxford Brookes University as senior Lecturer in clinical physiology. He is also the co -founder and chief scientist at a Swiss regenerative medicine company. In addition to academic teaching, research and clinical consultancy, he has operated a stress management practice in organisations for the past 15 years. Working with clients in the public and private sector, his approach focuses on measuring individual’s responses to occupational stress and developing tailored stress management strategies based on these profiles. Steve also has extensive experience in design and delivery of specialist well-being in the workplace programmes including sleep, nutritional support, health and immune function.

Steve has both a BSc and a PhD in Neuroscience.

Professor Mark Middleton- Professor of Experimental Cancer Medicine and Consultant Oncologist
Professor Mark Middleton is working on melanoma, the most serious form of skin cancer. He is based at the Churchill Hospital in Oxford where he is running several clinical trials testing new ways to treat the disease.

People with melanoma are often treated successfully with surgery, but unfortunately in some cases the cancer can come back. Professor Middleton is trying to crack the code of melanoma and identify ‘molecular fingerprints’ in blood and tumour samples that will predict if a patient’s cancer is likely to return. This trial, called AVAST-M, is also investigating whether a drug called bevacizumab could help to reduce the risk of melanoma coming back after surgery, and identifying which patients could benefit from this treatment.

Professor Middleton’s work will help us to understand which patients have a high risk of their cancer returning, and who will get the most benefit from bevacizumab. This research could lead to a new test enabling doctors to prescribe bevacizumab only to those patients whose cancer will respond, while sparing others from an unnecessary treatment. Work like this is bringing us a step closer to more personalised treatments for melanoma, helping to save even more lives.

Dr Thomas Nesselhut & Dr Jan Nesselhut MD
Institute fur Tumortherapie, Duderstadt, Germany

Dr Nesselhut treats patients with all types of cancers using cutting edge treatment which once included immunotherapy such as Newcastle disease virus combined with dendritic cell therapy. Also provided at the clinic is hyperthermia and ionised oxygen. Dr Nesselhut comes highly regarded and referred by top oncologists in the UK.

Dr Kate JamesIntegrative Medical Practice.
Dr Kate James qualified as a medical doctor in 2002 and through professional and personal experience her horizons have broadened and she has evolved her own Integrative Medical Practice. Her work with patients centres around simple and natural ways of supporting their conventional medical treatment, with a focus on what they can do to support themselves better.

Kelly McCabe BSc (Hons) RD Oncology Dietician
Kelly works for the NHS and as a specialist consultant at The London Oncology Clinic.
Oncology Dietitians and Nutritionists are the specialists within the clinical team who understand the most about how the food you eat impacts on your health. Kelly has over 20 years experience in sharing the practical insights needed to help people with cancer find the best options to soothe problems.

Professor Andrew Tutt
Professor Andrew Tutt is the Director of the Breakthrough Research Unit at King’s College London, a Reader in Breast Oncology and Consultant Clinical Oncologist. He qualified in medicine from Bristol University in 1990. After postgraduate training in general medicine he trained in clinical oncology at the Royal Marsden Hospital before gaining a Research Training Fellowship from the Medical Research Council to work in Professor Ashworth’s laboratory at The Institute of Cancer Research. Here he worked on functions of the BRCA2 breast cancer predisposition gene and was awarded his PhD in 2002. He cares for women with breast cancer as an oncologist in the multidisciplinary Breast Unit at Guy’s and St Thomas’ NHS Foundation Trust and is an faculty member of Section of Research Oncology at King’s College London.
Professor Tutt has, in collaboration with Professor Ashworth, developed a translational clinical trial programme focusing on cancers associated with functional deficiencies in BRCA1 and BRCA2. Dr Tutt’s leadership of the ICEBERG proof of concept trials for PARP inhibitors in BRCA1/2 cancers have led to a reappraisal of BRCA1/BRCA2 testing as a therapy companion diagnostic. He is currently Chief Investigator for the UKCRN Triple Negative Trial and the proposed Breast International Group Neoadjuvant PARP inhibitor Trial (NEPTUNE).

Dr Nicola Hembry BSc MBBS MSB PgDip is the Medical Director of Integrated Health Screening Ltd, which is a private integrated medical practice based in Clifton, Bristol.
She is a committee member of the British Society of Ecological Medicine and a member of the Independent Doctors Forum, the Society of Biology and the British Psychological Society. Her further qualifications are in nutritional medicine, clinical oncology and psychology.
Dr Hembry is also co-director of RGCC-Europe N & W Ltd with Dr Ioannis Papasotiriou MD PhD. This company facilitates the specialised cancer tests of RGCC International GmbH, and offers training and consultancy for RGCC’s cancer services in the UK.

Prof Dr med. Thomas Vogl
Prof Dr med. Thomas Vogl was appointed as professor of Diagnostic and Interventional Radiology in Frankfurt in 1999.
The Institute for Diagnostic and Interventional Radiology focuses on quality-assured radiological treatment of the highest scientific level, according to the latest radiation protection criteria.
Vogl is known for his works in the fields of interventional oncology, vascular procedures, multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), evaluation of contrast agent and MR-guided procedures.

Dr Seibenhuner
As a specialist in naturopathic treatment, Dr Gerhard Siebenhuener is an expert in alternative treatment techniques, practice owner and Head of the Dr Siebenhuener Practice Clinic in Frankfurt.
The Siebenhuener Practice Clinic at the Centre for Advanced Medicine in Frankfurt specialises in holistic integrative medicine. The alternative treatment techniques support the conventional treatments of his patients. These include, for example, complementary and alternative oncology, as well as the treatment of chronic conditions by identifying the root causes.
At the same time, it is the first objective of the expert to achieve the best possible regeneration of patients with chronic conditions.
Here, the analysis of weak points, detoxification, hyperthermia, infusion therapy and metabolic regulation play an important role.

Dr Siebenhuener specialises in the fields of internal medicine / general medicine, complementary oncology, lipidology, psychosomatic medicine (positive psychotherapy, herbal medicine (phytotherapy), biochemistry, biomedicine, physical medicine / laser, X.MAYR medicine, nutritional medicine and human identical hormone replacement therapy (hormone replacement therapy) in old age and for cancer.

These include, for example, complementary and alternative oncology, as well as the treatment of chronic conditions by identifying the root causes.
At the same time, it is the first objective of the expert to achieve the best possible regeneration of patients with chronic conditions.
Here, the analysis of weak points, detoxification, hyperthermia, infusion therapy and metabolic regulation play an important role.

Dr Siebenhuener specialises in the fields of internal medicine / general medicine, complementary oncology, lipidology, psychosomatic medicine (positive psychotherapy, herbal medicine (phytotherapy), biochemistry, biomedicine, physical medicine / laser, X.MAYR medicine, nutritional medicine and human identical hormone replacement therapy (hormone replacement therapy) in old age and for cancer.

Patricia Peat Dip Pall C Dip UTR
In her 20 years as an oncology nurse, Cancer Options founder Patricia Peat saw thousands of cancer patients struggle with difficult emotions: shock, fear, anxiety, grief, trepidation, uncertainty. Patricia set up Cancer Options to help guide and advice anyone who needs assistance with their own cancer care.

We have seen a review from Bristol University of the top 50 studies in the world on exercise and cancer. This concluded that people who took exercise developed fewer cancers and people with cancer who took exercise survived longer.

This ´longer survival´ was borne out in several specialist studies over the last 12 months. Women with breast cancer who do daily exercise survive 50 per cent longer than women doing none. These conclusions appeared in three separate research studies in Cancer Watch in less than a year. Exercise has many benefits to your health; a recent finding was how, after just 15 minutes your visceral fat started to break down. This is the fat you cannot see as it surrounds your internal organs. Because fat is such a good solvent it means that visceral fat holds these toxins against your major organs. Getting rid of it is therefore a very good thing!

There are many other benefits to physical fitness in fighting cancer. We have broken down the key focus areas.

a) Daily exercise is the key

Aerobic exercise floods the body with oxygen and rids it of waste via the lymphatic system. Just as blood is circulated through the body by the heart, exercise is what circulates the lymph. If the lymph doesn’t circulate, then the tissues become oxygen-depleted because they are clogged with metabolic waste.

Walking, Yoga, Qigong, and swimming are moderate forms of exercise that alkalize and oxygenate the body. The key for your optimum health is simply to find some type of exercise that you enjoy and will practice daily!

But this doesn’t mean massive intensity or excessive exercise as this can raise your acid levels. For daily exercise we are looking to do 30 minutes of moderate aerobic exercise with longer sessions such as walking at weekends. To do this we have purchased exercise DVD’s such as Davina McCall and Jillian Michaels and a rebounder. We have also set targets of places where we would love to walk. I regularly change what type of exercise I do to keep me interested. I currently have a trainer for half hour a week who mixes all kinds of exercise from resistance, cardio, HIIT, anything really.

One of the best ways to exercise is to jump on a rebounder, or mini-trampoline. As you bounce, your cells get gently massaged and the lymph is completely flushed within a few minutes, and is also gentle on your joints.

Rebounding
What is a rebounder?
Put simply – bouncing on a mini trampoline. Unlike regular trampolining, the aim isn’t to bounce high or perform gymnastic tricks; it is to perform a series of small, controlled movements. There’s no need for special instruction, you can use your Rebounder for bouncing, jogging or dancing. Rebounding could possibly be the most perfect exercise

Rebounding is a unique exercise in which a weightless state is achieved at the top of each jump and landing achieves twice the force of gravity on each bounce. This shift in gravity benefits every muscle and cell of the body and provides huge benefits to the lymphatic system. By bouncing, your cells get gently squeezed by the alternation of weightlessness and gravitational pull. As a result, toxins are flushed and nutrition floods your body.

The rebounding motion stimulates all internal organs, moves the cerebral-spinal fluid, and is beneficial for the intestines. Many immune cells such as T-lymphocytes and macrophages are self-propelled through amoebic action. These cells contain molecules identical to those in muscle tissue. All cells in the body become stronger in response to the increased “G force” during rebounding, and this cellular exercise results in the self-propelled immune cells being up to 5 times more active. These immune cells are responsible for eating viruses, bacteria and even cancer cells, so it is good that they be active. Jumping on a mini-trampoline directly strengthens the immune system, so it’s a big deal! When the outer coating of cancer cells has been dissolved by the enzymes trypsin and chymotrypsin, the immune cells attack the cancer cells. Therefore, supplementing one’s healing diet with enzymes, combined with rebound exercise are a useful way to combat cancer.

b) Oxygenation is vital
Cancer cells do not need oxygen as they are anaerobic. By oxygenating the environment will help the healthy cells and create an uncomfortable environment for cancer. To oxygenate the body we are combining exercise, deep breathing and relaxation, nutrition including lots of dark green vegetables which are rich in chlorophyll therefore full of oxygen. For deep breathing, which isn’t a natural thing to, we have bought an I Phone application by Saagara called Pranayama. It takes you through a 7 minute cycle of deep breathing and is so simple and quick to use.

Four Powerful Ways to Oxygenate Your Body
by Nancy Hearn, CNC, EFT-ADV

Healthy cells in your body are aerobic, meaning they need oxygen. Of all nutrients required by the human body, oxygen is second only to sunlight.
In 1931, Otto Warburg won a Nobel Prize for the connection he discovered between oxygen and cancer. His studies showed that the number one cause of cancer is a lack of oxygen in the cellular environment. Warburg determined that cancer cells are anaerobic, meaning they thrive in an oxygen-depleted environment. Conversely, cancer cells cannot live in an oxygen-rich environment.

Warburg also wrote about oxygen’s relationship to the pH of cancer cells and the body’s terrain. He said that cancer maintains a lower pH, as low as 6.0, due to lactic-acid production and elevated CO2. Warburg believed that higher pH (more alkaline) meant higher concentrations of oxygen, and vice versa.

What Warburg discovered for cancer is true for all degenerative disease. Oxygen and a healthy pH balance are the foundational keys to a healthy body. The following are four powerful ways to oxygenate and improve your body’s terrain.

Deep belly breathing—Shallow breathing (or chest breathing) causes a constriction of the chest and lung tissue over time, decreasing oxygen flow and delivery to your tissues. Deep, rhythmic belly breathing expands the diaphragm muscle, the cone-shaped muscle under your lungs, expanding the lung’s air pockets, invoking the relaxation response, and massaging the lymphatic system.

A simple breathing exercise anyone can do is to simply lie on the floor with a book on your stomach. Begin breathing by pushing the book up with your belly while breathing in through your nose. Fill the belly first with air, then the diaphragm and finally the chest. Reverse the process on exhaling. You can also join a class that reinforces deep-breathing techniques, such as Yoga, Qigong, or Tai Chi.

Ionized drinking water—I cannot overemphasize the importance of drinking the right water. Like the earth, we are approximately 70-75 percent water. Without proper hydration, our cells, tissues, and organs literally shrivel and wither on the vine. We need to drink between 50 and 100 percent of our body weight in ounces each day!

The question is what type of water should we drink? Tap water is loaded with chemicals and heavy metals. Bottled water is not much better, most of which is acidic and unhealthy. I also do not recommend distilled water or reverse osmosis water. Both waters are devoid of living energy and minerals, which are critical to our body’s acid-alkaline balance.

It is best to get a high-quality water filtration device for your home. I highly recommend the Kangen Water™ system because it produces pure, alkaline, ionized water that is six times more hydrating than other waters and also high in antioxidant potency. Go to www.kangen4wellness.com for more info. Other options are water jugs containing filters making the water more alkaline. We use this one; http://www.pure-aire.co.uk/product/pureaire-alkaline-water-jug/

Alkaline diet—One of the best ways to increase the alkalinity of our bodies is to eat a vegetarian diet with a high concentration of raw foods. If you’re not ready to eat mostly raw, organic food or to give up meat, I encourage you to educate yourself about which foods are more alkaline forming. Please see the Nutrition page.

c) Yoga harnesses the power of your body
Focussing the power of your body against cancer makes perfect sense. Yoga has been shown to reduce stress hormone cortisol levels enormously, and Tai Chi and Qigong also have significant benefits for minimal ´effort´. The same as an athlete achieves success by focussing concentration and using every physical advantage we can do the same against cancer and our main weapon in this is yoga. I’ve been learning about yoga for four years now and I am sure this section will grow as my knowledge increases. To get me started I used the Ten Minute Solutions DVD. I have started with the basic including the Sun Salutation as well as flexibility and relaxation. I then went onto DVD’s such as Tara Styles, and recently I have just joined a class. I do try to do some yoga every day and I like to improvise and go with the flow.

As with everything on this site it’s for all fighters and I welcome any advice.

d) Sleep is essential
The most important time for cell regeneration and fighting against cancer is when we sleep. Paradoxically right now you are probably finding it harder to sleep than any point in your life. As our main principle is to remove toxins we don’t find it acceptable to revert to sleeping pills (unless absolutely necessary). So to achieve the sleep the body needs we have some tools.
i) Just before bed eat a few almonds- they are rich in magnesium and help you get a more restful sleep.
ii) Use the sleep application or possibly even hypnotherapy to help you sleep and refer to the guidance in our mental health section to let you get back to sleep when you wake up in the middle of the night.
iii) Avoid caffeine.
iiii) This may be obvious, but ensure your bedroom is quiet, comfortable and dark.
v) Perhaps consider using lavender or other calming aromatherapy oils to provide a calming environment.

d) Clean Environment
Dirt and dust harbour toxins. It’s important that in your environment these are eradicated. Particularly where you sleep and ensure its dust and dirt free. Change bed linen regularly and clean right under the bed. When using any kind of cleaning chemicals remember that they add to the toxins in your environment and ventilate and use sparingly. It is possible to by bio friendly products.

e)Epsom Salt and Magnesium Salt
Most of us know about the importance of iron and calcium for our bodies, but what about magnesium? It is the second most abundant element in human cells and the fourth most important positively charged ion in the body. It helps the body regulate over 325 enzymes and plays an important role in organizing many bodily functions, like muscle control, electrical impulses, energy production and the elimination of harmful toxins.
Most of us are deficient in magnesium, so I’m going to put on my wise-granny hat on here and tell you this: soaking in a bath with epsom salt, which is high in magnesium, is one of the easiest ways to get a boost.
Magnesium deficiency helps to account for high rates of heart disease, stroke, osteoporosis, arthritis and joint pain, digestive maladies, stress-related illnesses, chronic fatigue and a number of other ailments. Who knew?!
Our magnesium levels have dropped by half in the last century due to changes in agriculture and diet. Industrial farming has depleted magnesium from soil and the typical diet contains much less magnesium than that of our forefathers. And in fact, the modern diet with its fat, sugar, salt and protein actually works to speed up the depletion of magnesium from our bodies.

What are the health benefits of using Epsom salt?
The wonders of Epsom salt have been well known for hundreds of years and unlike other salts, epsom salt has beneficial properties that can soothe the body, mind and soul. Some of the countless health benefits include relaxing the nervous system, curing skin problems, soothing back pain and aching limbs, easing muscle strain, healing cuts, treating cold and congestion, and drawing toxins from the body. One of the simplest ways to ease stress and stress-related problems is to soak in a tub full of hot water with a few cups of epsom salt. Some of the magical benefits of epsom salt include:

Eases stress and relaxes the body
Stress drains the body of magnesium and increases levels of adrenaline. When dissolved in warm water, epsom salt is absorbed through the skin and replenishes the level of magnesium in the body. The magnesium helps to produce serotonin, a mood-elevating chemical within the brain that creates a feeling of calm and relaxation. Research shows that magnesium also increases energy and stamina by encouraging the production of ATP (adenosine triphosphate), the energy packets made in the cells. Experts believe that bathing with epsom salt at least three times a week helps you to look better, feel better and gain more energy. Magnesium ions also relax and reduce irritability by lowering the effects of adrenaline. They lower blood pressure, create a relaxed feeling, improve sleep and concentration, and help muscles and nerves to function properly.

Relieves pain and muscle cramps
An epsom salt bath is known to ease pain and relieve inflammation, making it beneficial in the treatment of sore muscles, bronchial asthma and migraine headaches. In addition, it has been known to heal cuts and reduce soreness from childbirth. Mix a thick paste of epsom salt with hot water and apply to get soothing comfort. Epsom salt softens skin and will even neutralize foot odour.

Helps muscles and nerves function properly
Studies show that epsom salt can help regulate electrolytes in your body, ensuring proper functioning of the muscles, nerves and enzymes. Magnesium is also known to be critical in the proper use of calcium, which serves as a main conductor of the electric impulses in your body.

Helps prevent hardening of arteries and blood clots
Epsom salt is believed to improve heart health and help prevent heart disease and strokes by improving blood circulation, lowering blood pressure, protecting the elasticity of arteries, preventing blood clots and reducing the risk of sudden heart attack deaths.

Makes insulin more effective
Proper magnesium and sulfate levels increase the effectiveness of insulin in the body, helping to lower the risk or severity of diabetes.

Relieves constipation
Numerous studies have revealed that Epsom salt can be used to treat constipation. Taken internally, epsom salt acts as a detoxifying agent for colon cleansing. The salt acts like a laxative by increasing water in the intestines and can bring about temporary relief from constipation. However, it is strictly warned that Epsom salts should not be used to relieve constipation without the consultation of a physician.

Eliminates toxins from the body
This is the most important reason for cancer survivors to use Epsom salts in baths: The sulfates in epsom salt help flush toxins from acidic foods and heavy metals from the cells, which is essential when trying to remove chemotherapy and acidity from the body as well easing muscle pain and helping the body to eliminate harmful substances. Your skin is a highly porous membrane and adding the right minerals to your bathwater triggers a process called reverse osmosis, which actually pulls salt out of your body, and harmful toxins along with it. For a detoxifying bath, at least once weekly add two cups of epsom salt to the water in a bathtub and soak for 10 minutes.

Alternatively, dead sea salts or Himalayan salt if you prefer to have something less mineral based.

Magnesium salt
Most people are deficient in Magnesium. Magnesium is the second most abundant element in our bodies, and is used in regulating over 300 enzymes and reactions in the body.

Magnesium is the eighth most abundant mineral on earth, and the third most abundant in sea water. More importantly, it is the fourth most abundant mineral in the human body and it is necessary in over 300 reactions within the body.

Magnesium isn’t just abundant in the body, but vitally important too. Every single cell in the human body demands adequate magnesium to function, or it will perish. Strong bones and teeth, balanced hormones, a healthy nervous and cardiovascular system, well functioning detoxification pathways and much more depend upon cellular magnesium sufficiency. Soft tissue containing the highest concentrations of magnesium in the body include the brain and the heart—two organs that produce a large amount of electrical activity, and which can be especially vulnerable to magnesium insufficiency.

Proper magnesium ratios are important for the body to correctly use calcium in the cells. Even a small deficiency can lead to a dangerous calcium imbalance and lead to problems like calcification and cell death.

These additional dietary factors can also deplete magnesium:

  • Consumption of caffeine
  • Consumption of sugar (It takes 28 molecules of magnesium to metabolize a single glucose molecule! source)
  • Consumption of processed food
  • Consumption of alcohol
  • Consumption of produce from depleted soil
  • Consumption of foods high in phytic acid

Additionally, drugs like birth control pills, hypertension medicine, diuretics, insulin, and certain antibiotics (among others) deplete magnesium levels.

Magnesium is necessary for hundreds of functions within the body, but is especially important for:

  • Gives rigidity AND flexibility to your bones (more important than Calcium in many cases)
  • Increases bioavailability of calcium
  • Regulates and normalizes blood pressure
  • Prevents and reverses kidney stone formation
  • Promotes restful sleep
  • Helps prevent congestive heart failure
  • Eases muscle cramps and spasms
  • Lowers serum cholesterol levels and triglycerides
  • Decreases insulin resistance
  • Can prevent atherosclerosis and stroke
  • End cluster and migraine headaches
  • Enhances circulation
  • Relieves fibromyalgia and chronic pain
  • Treats asthma and emphysema
  • Helps make proteins
  • Encourages proper elimination
  • Prevents osteoporosis
  • Proper Vitamin D absorption
  • Protection from radiation
  • To aid weight loss
  • Lessen or remove ADD or ADHD in children
  • Proper digestion of carbohydrates
  • Emerging evidence is showing a preventative role in many cancers

Mental fitness is probably the most important thing in fighting cancer. Depending at what point you are in your treatment will depend very much on how you are feeling. The first thing, the second thing, the third thing and the only thing is that you need to turn triple negative breast cancer into a positive.

How to do this is within you but all I can share as I am not a clinical psychologist, is what works for me. To me the Ten Point plan is essential. The biggest effect on my mental state are negative comments even by health care professionals, statistics and the ‘stories’ that people like to impart. Let’s look at that.

I was firstly told that I had terminal cancer and nothing could be done. Then my research seemed to indicate that 10% of people survive for five years. As that was outdated this has now been reassessed as 30% of people. So about now you are thinking this isn’t too good. However, if you look at the rate of scientific progress (drug company conspiracy theories aside) in five years time ( I originally wrote this in 2012) it seems very likely that even triple negative breast cancer will be curable. So this isn’t an exercise in survival but just extending life until the cure arrives. So those 30% of people have a 100% survival potential. And I want to be one of them.

Out of a 100 people of a room how many, when they are told nothing can be done accept it?
How many accept chemotherapy and nothing else?
How many will maybe try one or two of the alternative therapies?

They are all shown to have a positive effect on cancer no matter what you believe. Are you up to 70% yet? Out of those that are left, how many will give 100% total dedication and focus to all of the aspects of the Ten Point Plan. In my head I am now in the top 1 or 2% which means I am going to beat this. Without any emotion that is just completely logical.

Having established my relationship with cancer I am empowered to live with cancer rather than die from it and can create a mental state to fight back and have my quality of life.

The next thing is to understand the importance of happiness and serenity. It’s something that you need to find within but also to impart to your loved ones. Its very easy to focus on feeling that it is unfair, on anger and on the right here, right now, rather than the future. Some things that I use to help me are;

  1. Music- I have created a playlist of happy tunes and the house always has happy music playing.
  2. Positive reading. Books such as Kris Carr’s Crazy Sexy diet. She also has cancer but has stopped the growth through her diet.
  3. Charity work and especially this website in the hope that we can help others.
  4. Being happy and laughing
  5. Planning for the future-Holidays and other aspirations
  6. Mood Board- Pin hopes and dreams and goals for years to come- Where do you want to be in 3 years time? How are you going to celebrate your next big birthday?
  7. Professional relaxation techniques- Breathing I Phone app- Prayanama- aids breathing correctly and slowly and Andrew Johnsons Hypnotherapy I Phone apps- relaxation and positivity. Meditation is essential too. I had never tried meditation until I was told that the cancer was incurable but since then I have used a free online method by Deepak Chopra who takes you through a 21 day cycle. It takes 15 minutes every morning. This too is available to use on a phone application but also to download.

Some other good motivational exercises;

Take a piece of paper. Draw a line top to bottom, straight down the middle. On the left write down all the things you really enjoy, your real friends, the things that are fun, the things you used to do that were fun. Things that give you real pleasure and, you just don´t do anymore. Old Hancock movies, Del boy videos, watching show jumping, going swimming, going to a show, seeing old ´lost´ friends. Whatever!!

On the right, write down all the things (and the people) that cause you grief, make you feel frustrated, guilty, and worthless.

Now one final box at the bottom of the page. Write down three things you´d really like to achieve in the next 5 years. Go on, you can, if you put your mind to it.

Now, stick this on the ´fridge door´. And start. Do more of the things on the left. Cut out the things (and people) on the right.

Go on; be true to yourself.

Feeling good about yourself may also include the way you look. Just because you have cancer and may be going through treatment doesn’t mean you can’t take pride in the way you look. It’s amazing how a touch of lip stick can lift your mood. There is a great charity that works closely at most hospitals, it is available at the Churchill Hospital, and where I go in Oxford called Look Good, Feel Better. They have sessions where they can teach make up, help with wigs and just generally get pampered. www.lookgoodfeelbetter.co.uk

Also, it is official- Shopping therapy makes you feel better too! Honestly, shopping is acceptable and if it lifts your mood then it all helps. My husband is crying at this news.

Visualisations
Visualisations reinforces the ‘thinking positive’ factor. Visualisations are so important and there is some scientific evidence and ‘miracle’ stories of those who regularly us visualisations of having recovered from serious illness and disease.
There are many self help books but for me ‘How your mind can heal your body’ by David R. Hamilton really helps to explain how it works as well give real life stories and actual visualisations for you to try yourself. You can actually visualize yourself getting better. You can visualize your body rebuilding itself, and in turn, your body will begin to respond. The other benefit is that the act of visualising, no matter what it is your visualising, reduces stress, relaxes the mind, and increases our overall mood which in turn lowers our blood pressure and allows our body to function at full capacity.

Affirmations
Positive affirmation or positive self-talk can benefit not only yourself but also other people that you interact with. Affirmation is the shifting of thoughts resulting from negative, dirty, and harsh experiences or ideas to a more positive note. It relies on the principle that you can only become successful if you tell yourself “I can do that” instead of saying “I can’t do that.”

If you think that positive affirmation affects only the subconscious mind then wait till you hear this. Studies have found out that people who constantly bombard themselves with positive words rather than entertaining negative thoughts and words have stronger muscles. Research claims that a person’s muscles become stronger and more active when the subconscious is filled with positive words. The same report indicated that the human muscles tend to become weak when a person thinks and verbalizes that he is tired or that he hates the world or that he cannot do a particular thing.

Aside from muscle strength, positive affirmation also affects your energy level. A jolly person is usually a result of a positive mind programming. Positive affirmation does not only affect the physical but also the emotional well-being of a person. Because of this, experts have always advised people to start their day with good and positive thoughts and words. Starting the day right would extend the vibrant feeling throughout the day and would even act as a multiplier effect to all other positive aspects in your life.

Positive affirmation brings to life a person’s capabilities, strengths, talents, and skills. Constantly repeating the things that you are capable of doing and forgetting hesitant feelings that usually hinder you from pursuing a particular goal can help a lot in achieving a positive result. A light outlook, a smiling face, and a worry-free aura are usually the characteristics of very successful people. The principle of positive affirmation leans on the basic tenets that the mind is just so powerful and what it says is usually followed and miraculously attained by the body.

Others also believe that positive affirmation carries with it some mysterious effects that no intellectual being has ever successfully explained. Experts simply claim that these positive affirmations can easily penetrate a person’s subconscious, thus affecting his actions, behaviour, and attitude. Affirmations must directly come from you and not from other people for it to become effective.

A person’s will is so powerful that it must be nurtured by constant repetition of positive self-talk. It serves as the engine for the human body to move and move faster. The lack of it would deprive you the chance to move forward from the first level of personal growth. Always remember that any form of development would require a clear affirmation of your goal and vision.

Positive affirmations are powerful statements that you can use during your self-talk. And to get the most benefit, you must use affirmations that are in the present tense. Follow these guidelines for developing good affirmation and you should do ok. A statement in the present tense is regarded by experts to be more effective than a statement in future tense because the element of time is an important factor that can affect your behaviour.

This is an ever growing section but certain truths are apparent. The main causes of cancer we believe in the western world are due to a) toxins in the environment, b) toxins in our food through processing, and c) refined sugars that feed cancer. Through nutrition we hope to remove the toxins that come into our body through the environment we live in, stop ourselves from adding to these toxins by ensuring that our food is of the right quality organic and chemical free, and to stop the assimilation of all refined sugars. Further to this there are a range of super foods and general dietary advice which have been shown to prevent cancer and also to prevent growth and in some cases even cause the death of cancer.

Furthermore there are some other principles that we need to consider in our food. Firstly that cancer thrives in an acid environment. It is imperative that the body is more alkaline. It’s fairly simple to buy pH testing strips and find out what your pH level is. Try to ensure it is approximately between 7 and 7.5 on the pH scale. Throughout the day your levels will alter so it is best to keep a chart over a period of 7 days and take an average from it. That said different parts of the body need different ph levels such as the gut. I believe that eating a mostly alkaline diet but being sensible and using the 80/20 rule then you can have a well balanced diet.

Alkaline diet—One of the best ways to increase the alkalinity of our bodies is to eat a vegetarian diet with a high concentration of raw foods. If you’re not ready to eat mostly raw, organic food or to give up meat, I encourage you to educate yourself about which foods are more alkaline forming. There are many acid-alkaline diet books and foods charts available online that you can study. This may get you started;  https://www.energiseforlife.com/acid-alkaline-food-chart-1.1.pdf

Foods on the pH scale

Acidic Foods-Below 7 on the pH scale:
Refined sugars and grains, white bread and pasta
Soda
Coffee
All meats and poultry and farmed fish
Dairy products including eggs
Alcohol
Heavily processed foods

Alkaline Foods-Above 7 on the pH scale:
Raw / lightly steamed vegetables
Almonds
Sprouts
Avocado
Lemon and Lime
Green juices and smoothies
Whole grain foods such as spelt, buckwheat, quinoa and rice
Beans and lentils
Wild fresh fish

Chlorophyll Foods
One of the most alkalizing foods that everyone will want to incorporate in their diets is chlorophyll. Remember, chlorophyll is the substance in plants that allows them to absorb light from the sun and convert that light into usable energy.

By eating a diet high in chlorophyll (dark green veggies and super greens), we drink in liquid oxygen. Super greens come in different formulas and may include wheatgrass, alfalfa grass, barley grass, chlorella, and so forth. Many of these come in powdered form and are mixed in water or juice.

Water
One of the most important factors with creating an alkaline body is water. The water from our taps and bottled mineral water contain many toxins that will disturb the harmony inside us causing illness and disease. It is best to create alkaline water to drink. This is easily done by many options such as buying an alkaline jug which filters the water. There are brands such as Biocera, or Pimag. Ph drops can be added to the water or even a home alkaline filter added to your tap.

Our body is created of 70% water; therefore we should consume foods and drinks in the same quantity. By having 70-80% raw alkaline foods and consuming large quantities of alkaline water with lemon, green tea and coconut water the body will become alkaline, removing acidifying toxins from every cell in the body and creating harmony. The other 20-30% can be neutral or slightly acid foods to create a perfect balance.

So with this in mind let’s consider diet…
Ensure all your food is organic or as much as possible. Use trusted sources and just because it says its organic do your own checks to make sure that it is. This is less easy on some perceived healthy foods such as apples and grapes which have the highest levels in processing and pesticide. Make sure you wash them thoroughly.

  • Nothing processed, which includes all red meats as toxins create cancer
  • No dairy
  • No refined sugar or bleached flour as this feeds cancer
  • Inclusion of known super foods*
  • Supplements
  • No alcohol

Super foods and Supplements
Here are foods that we eat and are specifically included for their anti carcinogenic, oxygenating and alkaline properties;

Green tea, wheat grass, barley grass – hugely powerful anti oxidants

Turmeric – The most powerful anti-inflammatory ever identified. It enhances the effects of chemo and reduces tumour size. It must be mixed with black pepper and ideally dissolved in olive oil.

Garlic, onions, shallots, leeks and chives – regulate blood sugar and reduce insulin. They promote death of cancer cells

Mushrooms – Shitake, and Coriolus. This is a tricky one as they are hugely acidifying however are essential in creating natural killer cells in the body. They stimulate the production of immune cells.

Cruciferous Vegetables – cabbages, broccoli, cauliflower. Do not boil – best raw or lightly steamed

Fruit & vegetables rich in carotenoids – carrots, yams, sweet potatoes, squash, tomatoes, apricots, and beets. They inhibit particularly aggressive cancers.

Watercress

Chilli

Herbs – Rich in oils of the Tarpene family that block cancer cell enzymes.
Rosemary, thyme, oregano, basil, mint

Citrus Fruits – These are generally acidifying however the ones shown below actually become alkaline in the body;
Limes
Lemons
Grapefruit

Himalayan Salt
Himalayan crystal salt is far superior to traditional iodized salt. Himalayan salt is millions of years old and pure, untouched by many of the toxins and pollutants that pervade other forms of ocean salt.

Known in the Himalayas as “white gold,” Himalayan Crystal Salt contains the same 84 natural minerals and elements found in the human body. This form of salt has also been maturing over the past 250 million years under intense tectonic pressure, creating an environment of zero exposure to toxins and impurities.

The health benefits of using natural Himalayan salt include controlling the water levels within the body, regulating them for proper functioning, promoting stable pH balance in the cells, including the brain, promoting the increased absorption capacities of food elements within the intestinal tract, aiding vascular health, and supporting healthy respiratory function. This is a must in exchange for normal salt.

Oncology Dietician and Nutritionist

Oncology Dieticians and Nutritionists are specialists who understand the most about how the food you eat impacts on your health. They share practical insights needed to help people with cancer find the best options to soothe problems.

Eating and enjoying a balanced nutritious diet has a key role to play. Up to 40% of people have experienced significant weight loss when their cancer is diagnosed or have nutrition problems, so being aware how to boost nutrition-health early on can be important.

Enjoying enough of the key food nutrients as well as trying to savour lots of good tastes is also important, as it will help you to:

  • Tolerate the optimal doses of certain treatments
  • Recover and heal more quickly
  • Feel better and stronger in yourself
  • Reduce fatigue
  • Control weight and changes of shape
  • Manage to enjoy more social times with friends and family
  • Reduce the likelihood of developing infections or problems that would require spending more time in hospital.

Staying at a healthy weight and eating healthily could make a significant contribution to how you might react to treatment. Maintaining nutrition intake is vital, but nutrient losses can easily occur without the right advice. Even in times of good health our immune system uses around 1/3 of the body’s total food nutrients.

During the various stages of cancer treatment there are often many reasons why your normal approach to eating may be more difficult or insufficient for your needs. Many patients feel food starts to become something that helps to manage their emotions, others that it is a difficult topic or source of tension within the family. You may notice shape or weight changes, rings or belts may feel looser or tighter, or you just may not feel your usual self. Looking at the way you eat and what you’re eating may well be a way forward to getting back on track, and this is when it could be helpful for you to seek guidance from Oncology dieticians and nutritionists if you don’t feel comfortable or maybe overwhelmed with knowing what information is correct.

Most people find the experience of getting expert guidance on the sorts of foods that their body may need more of, at certain stages of their treatment, and finessing what they normally enjoy to eat, as positive, empowering and often quite comforting.

Having met Kelly McCabe at The London Oncology Clinic, it was very interesting to find that my diet is very well balanced and with a few adjustments such as including up to ten eggs per week, which are high in amino acids and choline, which helps keep your cell membranes functioning properly and can only be found in food. Also I was advised to eat three portions of oily fish a week, such as mackerel and sardines, of course organic and not farmed or dyed. Kelly didn’t condone the alkaline as such but agreed with my dietary decisions including stopping dairy, processed sugars and meat. She does feel that one should be able to get all the necessary vitamins and minerals from our diet and foods however; she says that as I feel so well since I have been taking the supplements I could continue with them. She was very thorough in checking to ensure the ones I have been taking do not clash with each other and medication.

Having lived with this condition for so many years has had its ups and downs with times of progression and spread of the disease. Sometimes I have been unable to eat my usual diet and have come to terms with the fact that sometimes you just have to listen to your body and go with the flow. This is especially important when one is convalescing after chemotherapy or surgery etc. Therefore I say be kind to yourself and eat what makes you happy. Having a break every now and then is probably quite good for your system.

Supplements
Below is a list of supplements we have researched and their benefits. I would recommend choosing intuitively or alternatively contacting a nutritionist if you are unsure.

Vitamin D3
Vitamin D3 is an important factor in cancer prevention. Vitamin D activates the immune system to work against rogue cells. It has the ability to normalise and correct cancer cells. So it boosts the immune system, prevents cancer, AND can even help beat it.

My consultant has advised me to increase my D3 intake. Oh, it plays an important role in preventing all manner of illnesses too! Everybody with cancer should take vitamin D3.
If you cannot spend one hour a day in the sunshine, everybody with cancer should certainly include vitamin D3 supplementation in their integrative treatment package if they want to increase their personal odds of beating the disease.
Tests are available to purchase to find out your vitamin d level in the UK. This is available at www.vitamindtest.org.uk and is £30.

Calcium
To assist with the absorption of vitamin D3 it is essential to take one 500mg of calcium a day.

Matcha from Teapigs
Matcha is 100% natural, organic green tea leaves which have been carefully ground down to form a fine powder.It has been drunk in Japan as part of the tea ceremony for almost 900 years, and is used by Buddhist monks to keep them alert, awake and focused during long days of meditation.

We like to think of Matcha as a sort of superhero amongst teas, as its super-concentrated and packed full of the goodness we need to help keep us looking and feeling happy and healthy.
The tea leaves are grown under cover for the last two weeks of cultivation to produce lots of chlorophyll (the bright green good stuff).They are then dried and slowly ground between two granite rocks to a very fine powder. This is then packed immediately in a vacuum sealed tin, to lock in all the nutrients.

Our little superhero contains 137 times the antioxidants of regular green tea – wow! Antioxidant capacity can be measured by the ORAC (Oxygen Radical Absorbancy Capacity) and this shows us the ability of certain foods to protect us from nasty free radicals, which cause ageing and general damage to our cells. Matcha scores very highly on the ORAC table, towering above many of our well-known super-foods such as spinach, blueberries and goji berries!

CLA
CLA is a newly discovered good fat called “conjugated linoleic acid” that may be a potent cancer fighter. In animal studies, very small amounts of CLA have blocked all three stages of cancer: 1) initiation, 2) promotion, and 3) metastasis. Most anti-cancer agents block only one of these stages. What’s more, CLA has slowed the growth of an unusually wide variety of tumours, including cancers of the skin, breast, prostate, and colon. Human CLA research is in its infancy, but a few studies have suggested that CLA may have similar benefits in people. A recent survey determined that women with the most CLA in their diets had a 60 percent reduction in the risk of breast cancer.

Chlorella
Chlorella is a single-celled freshwater algae. Chlorella contains vitamin C and carotenoids, both of which are antioxidants. Chlorella is promoted as an herbal remedy for a wide range of conditions. Proponents claim it kills several types of cancer, fights bacterial and viral infections, enhances the immune system, increases the growth of “friendly” germs in the digestive tract, lowers blood pressure and cholesterol levels, and promotes healing of intestinal ulcers, diverticulosis, and Crohn’s disease. It is said to “cleanse” the blood, digestive system, and the liver. Chlorella supporters also say that it helps the body eliminate mould and process more oxygen.

Supporters state that chlorella supplements increase the level of albumin in the body. Albumin is a protein normally present in the bloodstream, and promoters claim it protects against diseases such as cancer, diabetes, arthritis, AIDS, pancreatitis, cirrhosis, hepatitis, anaemia, and multiple sclerosis.

Chlorella is said to prevent cancer through its ability to cleanse the body of toxins and heavy metals. Some web sites describe it as the perfect food, saying that it regulates blood sugar, kills cancer cells, strengthens the immune system, and even “reverses the aging cycle.”

Wheatgrass
If we look at oxygen as a bullet to kill cancer cells, then we should look at wheatgrass as a shotgun blast at treating cancer. The number of ways it deals with cancer is incredible. First of all it contains chlorophyll, which has almost the same molecular structure as haemoglobin. Chlorophyll increases haemoglobin production, meaning more oxygen gets to the cancer. Selenium and laetrile are also in wheatgrass, both are anticancer. Chlorophyll and selenium also help build the immunity system. Furthermore, wheatgrass is one of the most alkaline foods known to mankind. And the list goes on.

Acidophilus
These intestinal-friendly bacteria have been shown to have anti-cancer properties. Take 1 to 2 teaspoons of live lactobacillus daily, the one that is in the refrigerated section of the nutrition store. This can be added to a smoothie or a shake. Alternatively take tablets- 40 million probiotic cells.

Selenium
This overlooked mineral is a potent antioxidant or scavenger of carcinogenic free radicals. Studies have shown a lower incidence of colon cancer in people taking selenium supplements in the range of 100 to 200 mcg a day. Studies have shown that persons who have lower levels of selenium in their blood are more likely to have colon polyps, and those with higher levels of selenium have much less of a chance of getting cancer. Selenium is most effective when taken along with foods or supplements that are high in vitamin E. Consider taking 100 mcg of selenium a day as a supplement. Best sources of selenium in food are fish (especially red snapper), whole grains, and vegetables, depending on the selenium content of the soil they’re grown in. Other sources include: sunflower seeds and garlic. I have been advised that only 50mg per day is necessary. This can be taken in the form of a supplement or two brazil nuts each day.

Bromelain
This enzyme is often used by itself as a supplement to aid in various ailments and boost general health. It derives from pineapple cores. There are also quite a few additional health benefits that may be lesser known than its most common uses. It has been linked to better heart and circulatory health, improvement in asthma and other breathing conditions and improved immunity.

Bromelain is particularly known for being very efficient at breaking down proteins which accounts for its common use as a digestive aid. Fibrin is a protein that is used in the clotting and thickening of blood. Bromelain works as a blood thinner since it assists in breaking down this substance. This means it may allow blood to flow more freely through the circulatory system. Thinner blood is associated with lower chances of stroke, heart attack, and other heart and circulatory issues.

Bromelain has also been linked to the improvement of breathing conditions that occur due to thicker mucus such as asthma. It has the same effect on mucus as it does on blood in that it thins the consistency. This makes it easier for asthma patients to breathe since the mucus is thinner and therefore not clogging their bronchial tubes.

It has also been implicated in the improvement of certain inflammatory skin conditions. This could include acne, rosacea, dermatitis, eczema, and psoriasis.

While most people think bromelain is found in the fruit of the pineapple, it is primarily found in the stem. This is why it may be preferable to buy a supplement if you are looking for the specific therapeutic benefits this enzyme can offer.

In addition to the anti-inflammatory and anti-coagulant properties bromelain exhibits in the human body, it has also shown promise as an immunity booster. Studies have indicated it may enable certain immunity enhancing receptors in the body.

This in turn may strengthen the immune response by enhancing the response of the body’s front line immune defence, T-cells. In other words the enzyme has an enhancing effect on the immune response already in place. It helps by enabling the other mechanisms to work more efficiently together and “communicate” better with one another.

Trifolam Pratense (Red Clover)
Red clover has a long history as a medicinal herb, and it has been used for a variety of conditions, including as a blood and lymph fluid cleanser. Red clover contains numerous bioactive compounds, some of which display antioxidant, blood thinning and hormonal properties.

Astragalus Membranaceous
Astragalus has been used in Traditional Chinese Medicine (TCM) for thousands of years. It was often combined with other herbs to strengthen the body against disease. Astragalus is called an adaptogen, meaning it is thought to help protect the body against various stresses, including physical, mental, or emotional stress.

Astragalus may help protect the body from diseases such as cancer and diabetes. It contains antioxidants, which protect cells against damage caused by free radicals, byproducts of cellular energy. Astragalus is used to protect and support the immune system, for preventing colds and upper respiratory infections, to lower blood pressure, to treat diabetes, and to protect the liver.

In the United States, researchers have looked at astragalus as a possible treatment for people whose immune systems have been weakened by chemotherapy or radiation. In these studies, astragalus supplements seem to help people recover faster and live longer.

Ashwagandha
Ashwagandha herb – also known as Indian winter cherry – is a shrub cultivated in India and North America whose roots have been used for thousands of years by Ayurvedic practitioners. Several studies over the past few years have looked into whether this herb has anti-inflammatory, anti-tumour, anti-stress, antioxidant, mind-boosting, immune-enhancing, and rejuvenating properties

Cleavers
Cleavers is said to be an excellent lymphatic tonic, assisting in the detoxification of tissues and the immune system. Cleavers is also used in urinary and skin ailments, including kidney and gall bladder gravel and urinary tract infection.

Chaparral
It is thought to be a useful herb in fighting the symptoms of cancer and is often recommended by herbalists when cancer is diagnosed in the stomach, liver, or kidneys. This is due to the powerful antioxidant properties of the herb. Some studies have been carried out that suggest the herb may be able to inhibit. Chaparral tea is traditionally used to relieve respiratory problems such as bronchitis and colds. It is a natural expectorant and can help to keep the airways clear of excess mucus. The herb has anti-inflammatory properties and can relieve conditions such as arthritis.

Bio Bran
BIOBRAN MGN3, a nontoxic glyconutritional food supplement (or functional food) made from breaking down rice bran with enzymes from the Shitake mushroom has been clinically proven to help powerfully enhance depleted immune systems. So successful is this unique and patented MGN3 arabinoxylan supplement at stimulating immune function that Professor M. Ghoneum of Drew University of Medicine and Science has stated: “I have been researching immunomodulators for over 30 years now and Biobran MGN3 is the most powerful immune complex I have ever tested.”

Curcumin
Curcumin is a natural extract from the spice Turmeric. Turmeric is derived from the plant Curcuma Longa, a member of the ginger family. Curcumin has been studied extensively regarding its role in preventing and treating cancer. Curcumin may help prevent and treat cancer by several mechanisms. First, it may help block certain dangerous chemicals’ cancer causing effects. Also, curcumin may block the growth of cancer cells. Additionally, curcumin may stop the growth of blood vessels into tumours which in turn prevents the tumours from growing. Curcumin is best absorbed into the body when combined with black pepper and omega 6 oils. I take mine with an omega 6 capsule.

Mushroom Complex including Coriolus and Shitake
Mushroom extracts stimulate natural killer cell activity. Natural killer cells release cytokines that strengthen the immune response.

IP6 and Inositol
The combination of IP6 and inositol has been shown to be an effective antioxidant and booster of immune function. The combination is especially helpful in boosting the activity of white blood cell known as “natural killer or NK” cells. These white blood cells get their name because they literally kill diseased cells, viruses and other infecting organisms. They play a major role in protecting the body against infection. While Ip6 can boost NK cell activity, the combination exerts even greater enhancement.

Inositol hexaphosphate (IP6) is a chemical found in beans, brown rice, corn, sesame seeds, wheat bran, and other high-fibre foods. It is converted into compounds in the body that are used by cells to relay outside messages to the cell nucleus. IP6 also aids the body in its use, or metabolism, of calcium and other minerals.

Proponents call IP6 a “natural cancer fighter” and claim it slows or reverses the growth of various forms of cancer, including breast, colon, and prostate cancers. It is thought to be an antioxidant, a compound that blocks the action of free radicals, activated oxygen molecules that can damage cells. It may help to prevent the abnormal signals that tell a cancer cell to keep growing from reaching the cell’s nucleus. Some research shows IP6 slows abnormal cell division and may sometimes transform tumour cells into normal cells. Supporters also claim it effectively prevents kidney stones, high cholesterol, heart disease, and liver disease.

AFA’s
AFA, which stands for Aphanizomenon flos-aque is one of a number of species of Blue Green Algae.AFA, like wheatgrass is extremely rich in chlorophyll in fact it is the most concentrated source known to mankind! It contains all of the amino acids making it complete protein. Amino acids are vital for the production of serotonin based neurotransmitters which means that AFA is the perfect food for calming and soothing the nervous system. Algae contains a wide array of healthful compounds, most importantly in a form that allows them to be easily absorbed and assimilated. These include Beta-Carotene, and other carotenoids, (carotenoids are powerful antioxidants thus able to support the growth of healthy normal tissue and help to overpower and destroy abnormal cells) AFA is also a good source of Omega-3 essential fatty acids. It also contains a substance called PEA which has been widely researched and is known to support mental focus, mental energy, and balance mood. It is well recognised for reducing cravings for alcohol and drugs and balancing blood sugar levels too. Further, we know AFA contains a powerful anti-inflammatory compound called phycocyanin, a selective COX-2 inhibitor which also gives AFA it’s blue colour. This assists our bodies to heal and support any internal inflammatory processes by working naturally on the same pathways as anti inflammatory prescription drugs. Algae contains a number of substances which support the body in its excretion of toxins including heavy metals, pesticide residues, and also drug residues. AFA seems to stimulate the migration of natural killer cells, involved in eliminating cancerous and virally infected cells.

N-acetyl cysteine
N-acetyl cysteine, a modified form of the amino acid cysteine, is a powerful antioxidant that helps your body to generate glutathione and prevent cellular damage. N-acetyl cysteine is given intravenously in hospitals to prevent liver damage. As a dietary supplement, N-acetyl cysteine has been shown to prevent the onset of flu symptoms and also benefit a number of chronic lung conditions.

Co Enzyme Q10 For all its broad health benefits there is still yet another exciting role for Coenzyme Q10 (CoQ10) that offers promise for those challenged with cancer. CoQ10 is a naturally occurring compound found in every cell in the body where it plays a critical role in the mitochondria that burn or oxidize food for fuel. Levels of CoQ10 decline as we age which leads to speculation that certain diseases and aging are a result of this diminished enzyme.

The scientific community is taking another look at CoQ10 due to encouraging evidence that suggests CoQ10 has a positive impact in battling cancer. If a patient chooses chemotherapy drugs, rather than less harmful alternative treatments, it appears the drugs are more effective battling cancer if CoQ10 is added as a supplement, even though irreversible damage is inflicted from the toxic drugs. One of the reasons chemotherapy doesn`t cure more cancer is because there are inherent toxicity limits to the dosage administered. While cancer is being eradicated by high dosage chemotherapy treatment the overwhelming damage to healthy cells and permanent immune suppression can be severe enough that treatment must be discontinued or the patient is left to face fatal infections.
CoQ10 has proven itself as a tissue-protecting antioxidant molecule enhancing brain and cardiovascular health. Now it seems this multi-faceted enzyme`s role may have expanded to be a key nutrient in the battle to kill cancer cells and protect healthy cells from undergoing malignant damage.

Olive Leaf Extract
Olive leaf extract helps in strengthening the immune system. It stimulates the production of phagocyte which builds up immune cells. Laboratory tests have stated that it hampers the production of amino acids that support the growth of virus. It is also effective in combating problems of cholesterol and blood pressure. These are the two most common illnesses of today. The oleuropein compound present in Olive Leaf Extract keeps a check and prevents the further accumulation of bad cholesterol on the blood. It is also known for its anti oxidant properties. Olive leaf extract is also known to treat certain bacterial infections. It also acts as a powerful antiviral.

Medicinal mushrooms: Chaga and Reishi and Reishi Spores
These would need to be prescribed by a Chinese herbalist.

Chaga is used for the treatment of many forms of cancers and tumours in the Siberian regions. It is also used for treating digestive disorders as well as different kinds of bacterial and viral infections. The local people in the Siberian Mountains prepare it in powder form and drink it as tea. They also inhaled its smoke and apply it to their skin to heal their rashes and skin injuries.
Due to their regular consumption of chaga, these indigenous people have very low oncologic diseases. Many of them have been documented to live for over 100 years. But chaga was completely unknown to the rest of the world until the famous author Alexander Solzhenitsyn mentioned it in his book “Cancer Ward”. In the book, he mentioned how chaga was able to heal the cancerous diseases of some of the book’s characters. Today, chaga is acknowledged as a “cancer-tumour herb” and is very much sought after in Asia and the rest of the world as a “cure-all” herbal medicine.

Reishi and broken reishi spore is used widely in Japan and China as part of the standard supportive treatment for some types of cancer i.e. as an adjunct alongside radiotherapy and chemotherapy. It has a natural immunomodulating and strengthening effect, innately supporting immune response.
According to Eastern thought, the body needs to defend itself against threats to its “equilibrium.” These threats can be physical, such as viruses and bacteria that cause infection; emotional, such as stressors that cause anxiety; or energetic, in that they reduce alertness. Whatever the threat, reishi helps the body maintain its defence against these threats to its equilibrium, helping the body to maintain balance. In this sense, diseases like heart disease and cancer mean that the body is out of balance, which is why an equilibrium-enhancing remedy such as  reishi can help so many diverse ailments.

Skeptics can doubt the previous explanation as Taoist “mumbo jumbo,” but laboratory research proves many of reishi’s medicinal applications. As Dr. Andrew Weil writes, reishi “has been the subject of a surprising amount of scientific research in Asia and the West.” Research shows that the polysaccharide beta-1, 3-D-glucan in reishi boosts the immune system by raising the amount of macrophages T-cells, which has major implications for people suffering from AIDS and other immune system disorders. However, reishi may help the body defeat cancer in not just one, but four ways. In addition to boosting the immune system, the glucan in reishi helps immune cells bind to tumor cells. Many experts believe that it also actually reduces the number of cancerous cells, making it easier for T-cells and macrophages to rid the body of them. Another substance in reishi, called canthaxanthin, slows down the growth of tumours, according to “Prescription for Dietary Wellness” author Phyllis A. Balch and other experts. As a result of these amazing anti-cancer abilities, laboratory research and traditional medicinal usage of reishi to fight cancer is so positive that the Japanese government officially recognizes it as a cancer treatment.

Artemisinin
Artemisinin is the active substance extracted from Artemisia annua or sweet wormwood. It is known for its effect on the malaria parasite, Plasmodium, and in recent years has been extensively studied for its use in cancer treatment. Artemisinin has been shown to have anti-proliferative effect on a number of human cancer cell types.
It works by destroying cancer cells in the same mechanism of action as it kills the malaria parasite. Both malaria parasites and cancer cells isolate and accumulate iron. Artemisinin is selectively toxic to iron-loaded cells. The iron in our red blood cells is not free but is bonded and therefore our red blood cells are not affected by Artemisinin. Cancer cells are thirsty for blood to support their fast growing action and therefore take up and accumulate relatively larger amounts of iron than normal cells. Artemisinin has two oxygen atoms which react with the iron in the cancer cells and then form reactive free radicals that kill the cancer cells.

Lycopene
Lycopene is a naturally occurring chemical that gives fruits and vegetables a red colour. It is one of a number of pigments called carotenoids. Tomatoes are great source of this, and for once cooked is better than raw. This can be taken in supplement form too. Lycopene is a powerful antioxidant that may help protect cells from damage.

Symprove Probiotic
Symprove is a water-based multi-strain supplement that contains 4 unique strains of live activated bacteria. These include:  L. rhamnosus, E. faecium, L. acidophilus, and L. plantarum. Normally a healthy gut would already contain all four of these, however when it doesn’t, it can soon become unbalanced. Having a healthy gut is where the immune system is strongest, therefore using something proven to help the gut such as Symprove is essential.

All of the above are very helpful, however I have changed what I take and mixed them up over the years. This could be where seeking professional advice is useful, by going with your instincts or simply trying them out and seeing what works for you. It is best to use supplements for three months before changing them to see if they benefit you.

 

Nutrition ideas
One of the best ways to get nutrition out of food is to make it into a smoothie or juice. Juicing is great as the body can consume many more nutrients this way than eating them. The key is to eat as much raw as possible as cooking depletes the positive effects of the food and to maintain a balance of 80/20: 80% alkaline and 20% acidic. For reference on diet please see the Crazy Sexy Diet and The pH Miracle on the resources page.

 

Here are a few ideas that I currently use:

Breakfast Juice
Cucumber
Celery
Dark leaves such as spinach or kale
Wheatgrass powder
Stem ginger
Milled flax
Plus supplements
Super Food Smoothie
Beetroot
Apple
Broccoli
Watercress
Curcumin/ Black pepper
Apple Cider vinegar (from the Mother)
Olive oil
Flax seeds
Sesame Seeds

Throughout the day drink plenty of alkaline water and green tea.

Meals
For me, changing to a vegan diet, let alone a vegetarian one was a gradual process. I don’t ever go hungry as I can eat as much as I like. I have found as the seasons change that the proportion of raw meals is reduced as my body starts to crave warmer, earthy foods.

Here are some ideas;

Salads full of fresh organic raw vegetables including avocado, Lightly cooked stir fry’s, homemade soup, spelt pasta with vegetables and sprouts. The list is endless. The books already mentioned have amazing recipes which are easy to use and create. It all takes a little adjusting to I have never felt so alive and happy and full of energy I am convinced that this is definitely helping me.

Alcohol
This is a tricky one for me. However, it has been proved that cells combined with pure alcohol, ethanol in a petri dish became cancerous. Therefore it is advised that once cancer has been diagnosed that it is best not to drink alcohol. This is of course not supported by most doctors. However, that said, I have been advised that in my case it would be fine for me to have a few glasses of something every week or so with a couple of days break in between. The key is to stay happy and if stopping things such as drinking, make you feel stressed then being sensible having some would be fine.

Desserts
I have been advised that having a dessert every few weeks or once a month would be absolutely fine. In fact having dark chocolate is essential in this diet and snacking on dark chocolate is a must! Oh ok then! 🙂
It goes without saying that it’s pointless to do all this great stuff removing toxins from your body if you then use a chemical washing up liquid. So please change your home cleaning products too. Take care of you and your world.

 

The Ketogenic Diet


Another diet that has particular interest for cancer patient is the ketogenic diet. There has been some scientific evidence that it can stop metastases.

All cells, including cancer cells, are fuelled by glucose. But if you deprive them of glucose, they switch to the alternate fuel, ketone bodies.

All except cancer cells. A defect prevents them from making the switch to using ketone bodies as fuel and therefore, cancer cells can only survive on glucose. All other cells can use either glucose or ketone bodies.

“Your normal cells have the metabolic flexibility to adapt from using glucose to using ketone bodies. But cancer cells lack this metabolic flexibility. So we can exploit that” says Dr. D’Agostino, who researches metabolic therapy.

When he and his team of scientists at the University of South Florida removed carbohydrates from the diets of lab mice, the mice survived highly aggressive metastatic cancer even better than when they were treated with chemotherapy.

What is Ketosis?


Ketosis means that the body is in a state where it doesn’t have enough glucose available to use as energy, so switches into a state where molecules called ketones are generated during fat metabolism. Ketones can be used for energy, and have a special property – they can be used instead of glucose for most of the energy needed in the brain, where fatty acids can’t be used. Also, some tissues of the body “prefer” using ketones, in that they will use them when available (for example, heart muscle will use one ketone in particular for fuel when possible).

Does Ketosis have any Negative Effects?

The ketosis produced by fasting or limiting carbohydrate intake does not have negative effects in most people once the body has adapted to that state. The confusion on this point is mainly due to the fact that people who lack insulin, mainly Type 1 diabetics or insulin-dependent Type 2 diabetics, can get into a dangerous state called diabetic ketoacidosis. In ketoacidosis, ketones levels are much higher than in the ketosis produced by diet. The ketosis caused by diet has been referred to as dietary ketosis, physiological ketosis, benign dietary ketosis (Atkins), and, most recently, nutritional ketosis (Phinney and Volek), in an attempt to clear up possible confusion with ketoacidosis.

A second source of confusion is that there is a transition period while the body is adapting to using fats and ketones instead of glucose as its main fuel. There can be negative symptoms during this period (fatique, weakness, light-headedness, headaches, mild irritability), but they usually can be eased fairly easily. Most are over by the first week of a ketogenic diet, though some may extend to two weeks. Athletes who closely track their performance may notice more subtle effects up to 6-8 weeks from the start of the diet, and there is some evidence that it may take even longer, up to 12 weeks, for 100% adaptation.

What Do People Eat on Ketogenic Diet?

Carbohydrate – Most of what determines how ketogenic a diet is how much carbohydrate is eaten, as well the individual’s own metabolism and activity level. A diet of less than 50 or 60 grams of net (effective) carbohydrate per day is generally ketogenic. However, athletes and people with healthy metabolisms may be able to eat 100 or more grams of net carbohydrate in a day and maintain a good level of ketosis, while an older sedentary person with Type 2 diabetes may have to eat less than 30 net grams to achieve the same level.

Protein – When people first reduce carbohydrates in their diets, it doesn’t seem as though the amount of protein they eat is as important to ketosis as it often becomes later on. For example, people on the Atkins diet often eat fairly large amounts of protein in the early stages and remain in ketosis. However, over time some (perhaps most) people need to be more careful about the amount of protein they eat as (anecdotally) the bodies of many people seem to “get better” at converting protein into glucose (gluconeogenesis). At that point, each individual needs to experiment to see if too much protein is throwing them out of ketosis and adjust as necessary.

Fat – Most of the calories in a ketogenic diet come from fat, which is used for energy. The exact amount of fat a person needs to eat will depend on carbohydrate and protein intake, how many calories they use during the day, and whether they are losing weight (using their body fat for energy). Depending on these factors, somewhere in the range of 60-80% of calories will come from fats on a ketogenic diet (even up to 90% on, for example, the Ketogenic Diet for Epilepsy). People tend not to overeat on diets this high in fat, so calorie counting is rarely necessary.

When eating this large amount of fat, you can imagine that the types of fats consumed is very important. Many authors advise steering clear of oils that are high in polyunsaturated omega-6 fats (soy, corn, cottonseed, safflower, etc). Dr. Stephen Phinney, who has been doing research on ketogenic diets since the 1980’s, has observed that people don’t do as well when they are consuming a lot of these oils (mayonnaise and salad dressings are a common source). This could be because omega-6 fats can be inflammatory, especially in large amounts, or some other factor, but people didn’t feel as well or perform as well athletically in his experiments.

On the other hand, fats high in medium-chain triglycerides, such as coconut oil and MCT (medium chain triglyceride) oil are often encouraged, as these fats are easily turned into ketones by the body. In general, people on ketogenic diets tend to consume a lot of foods high in monounsaturated and saturated fats such as olive oil, butter, avocado, and cheeses. The “high oleic” types of safflower and sunflower oils (but not the regular forms of these oils) are also good choices, as they are high in monounsaturated fats and low in polyunsaturates.

How Long Does it Take to Get Into Nutritional Ketosis?

It varies, but it often takes 2 to 4 weeks to consistently achieve the target ketone levels of nutritional ketosis, especially because diet tweaking is often necessary.

How High Should My Ketones Be?

People who have studied nutritional ketosis generally advise shooting for a target of a blood ketone level of .5 mmol/L – 3 mmol/L, though it can go as high as 5 without problems.

How to Measure Your Ketones

Measuring blood ketones is the most reliable method. There is a home blood test you can use, but the strips can be very expensive. An alternative is to measure ketones in the urine with a dipstick test, which is much more accessible and inexpensive. However, this method is much less reliable and as time goes on and the body adapts to ketosis, it becomes even less reliable. On the other hand, I know a couple of people who have been measuring urine ketones for years and still find value in it.

I had a one to one meeting with a dietician who specialises in the ketogenic diet called Patricia Daly. Her details are: http://www.nutritionchoices.ie/

She has also devised an online book on how to use the ketogenic diet with meal plans. Here is a link to her book for 19.90

Euros: http://www.nutritionchoices.ie/ketogenicdiet.html

 

With experience over the years I have found what works and what doesn’t work. At times of intense treatments I simply have to go with what my body asks for; which maybe meat, include dairy, and carbohydrates. Be kind to yourself but always know that eating foods that are unprocessed, with in a healthy portion and regularly will really help you as TNBC survivor and your loved ones.

Opinions on chemotherapy are probably the most widely disparaging in the treatment of cancer. As you will have gathered from the ten point plan nothing is exclusive. In fact the opposite everything is inclusive. Chemotherapy is incredibly individual both in which drugs needs to be administered and also in the effect of those drugs will have on an individual. When you combine this into what state of cancer you are at it makes discussion at anything less than a clinical level almost irrelevant. As such on this site, unless we receive some ground breaking information or scientific breakthrough our only discussion on chemotherapy will be in terms of dealing with it as a treatment and the side effects that it causes. It may be that you personally find the treatment unable to bear. That still leaves you with 9 out of 10  and in that surviving percentage.

As my treatment progresses I will share my own treatment with you but thus far I was diagnosed in Sept 2010 with breast cancer in my right breast- the tumour was 15mm. I had a wide local excision on the 1st October to remove the tumour and on diagnosis it was discovered to be triple negative breast cancer. This was then followed by another operation as the surgeon had identified that there was no clear margin on the 30th October and declared a success. Treatment then commenced in the form of 6 x FEC chemotherapy, then 4 weeks of radiotherapy, finishing in May 2011.

In October 2011 I had another mammogram and ultrasound and was told that it was totally clear.

From November 2010 until January 2012, I had an “inflamed stitch” as we were advised. This “stitch refused to heal and eventually became pusy. So this was surgically removed and on analysis it was found to be cancerous. I was then referred for another CT and MRI scan which found the breast cancer had reoccurred in the same breast, this time two tumours 45mm and 5 mm. It was also advised that it hadn’t spread to any other part of the body.

I had a full mastectomy in February 2012 and have since been prescribed 100 mg of Docetaxel every three weeks for 6 sessions up until 13th June.

During this treatment period I suffered badly with a chest infection and convinced the oncologist to book a CT scan on my chest. This was done on the 2nd July 2012.The following day at my Oncology appointment the decision was made to stop chemotherapy due to numbness in fingers and toes having completed 4 cycles of chemotherapy.

Then I was told that my CT scan showed 5 pulmonary nodules in both lungs combined, ranging from 3mm to 6mm, which had grown during the chemotherapy since the scan in February. They have advised that it is secondary breast cancer.

At this point they didn’t advice any treatment other than palliative care and the only information was that it is incurable. I was 35 at time of the first diagnosis at the time of the re diagnosis of incurable I was 37 years old. I am today 40 and a half years old!

Looking forward we are now going to explore all options available to us. What becomes immediately apparent is that not all options will be available on the NHS but some can be obtained. For example Avastin (bevacizumab) costs £20800 for ten months but is highly recommended for cancer that has spread to other parts of the body. We wait to seek advice from the oncologists from the Churchill hospital until we have a firm plan.

Below are the names of some drugs we have researched.

  • Avastin- not available on the NHS- can be obtained by the Cancer Drugs fund
  • Carboplatin- Full details of this treatment are on the New Developments page. New Developments
  • Cisplatin is first generation platinum drug (treats lung, bladder cancer)
  • Capecitabine (xeloda) combines with Avastin (online it says to use capecitibine with docetaxel)
  • Vinorelbine- tablet or injection, can be used with carboplatin.
  • Eribulin-works by stopping (inhibiting) the cancer cells from separating into two new cells. So it blocks the growth of the cancer. It is a type of drug called a microtubule inhibitor. This chemotherapy drug has quite good results for metastasised triple negative breast cancer
Clinical trials are making some radical break throughs recently reported in the news. Here is the link for all clinical trials available in the UK. Use key words to search the database. If there is something there that could be helpful ask your oncologist to be referred.
http://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial

A point we would like to add is that we have now discovered it is possible for the cancerous tumour once removed to be tested to see which chemotherapy is effective for ‘your’ cancer. This would eliminate you going through the pain and discomfort and possible reoccurrence. Sadly this is not something available on the NHS.

When diagnosed with triple negative cancer the first thing is to get your genes tested. I didn’t but this element is really important in the treatment that you will receive from thereon. Results can take a long time to come back from 1-3 months and although this can be accelerated by sending your test abroad to the USA. The cost is around £3000. Once you have the test results some truly remarkable treatments may be available and this seems to be the most likely route to one day finding a cure. On a personal note it is very troubling that more resource isn’t dedicated to this by the major cancer charities and the NHS and we potentially feel that some further investigation into the role played by drug companies may be warranted after all a lab derived cure would immediately impact on their trillion dollar revenue stream and chemotherapy drugs. Discuss?

Genetics
About 5% to 10% of breast cancers are thought to be hereditary, caused by abnormal genes passed from parent to child.

Genes are particles in cells, contained in chromosomes, and made of DNA (deoxyribonucleic acid). DNA contains the instructions for building proteins. And proteins control the structure and function of all the cells that make up your body.

Think of your genes as an instruction manual for cell growth and function. Abnormalities in the DNA are like typographical errors. They may provide the wrong set of instructions, leading to faulty cell growth or function. In any one person, if there is an error in a gene, that same mistake will appear in all the cells that contain the same gene. This is like having an instruction manual in which all the copies have the same typographical error.

BRCA1 and BRCA2 genes
Most inherited cases of breast cancer are associated with two abnormal genes: BRCA1 (BReast CAncer gene one) and BRCA2 (BReast CAncer gene two).

Everyone has BRCA1 and BRCA2 genes. The function of the BRCA genes is to repair cell damage and keep breast cells growing normally. But when these genes contain abnormalities or mutations that are passed from generation to generation, the genes don’t function normally and breast cancer risk increases. Abnormal BRCA1 and BRCA2 genes may account for up to 10% of all breast cancers, or 1 out of every 10 cases.

Having an abnormal BRCA1 or BRCA2 gene doesn’t mean you will be diagnosed with breast cancer. Researchers are learning that other mutations in pieces of chromosomes — called SNPs (single nucleotide polymorphisms) — may be linked to higher breast cancer risk in women with an abnormal BRCA1 gene as well as women who didn’t inherit an abnormal breast cancer gene.
Women who are diagnosed with breast cancer and have an abnormal BRCA1 or BRCA2 gene often have a family history of breast cancer, ovarian cancer, and other cancers. Still, most people who develop breast cancer did not inherit an abnormal breast cancer gene and have no family history of the disease.

You are substantially more likely to have an abnormal breast cancer gene if:

  • You have blood relatives (grandmothers, mother, sisters, and aunts) on either your mother’s or father’s side of the family who had breast cancer diagnosed before age 50.
  • There is both breast and ovarian cancer in your family, particularly in a single individual.
  • There are other gland-related cancers in your family such as pancreatic, colon, and thyroid cancers.
  • Women in your family have had cancer in both breasts.
  • You are of Ashkenazi Jewish (Eastern European) heritage.
  • You are African American and have been diagnosed with breast cancer at age 35 or younger.
  • A man in your family has had breast cancer.

If one family member has an abnormal breast cancer gene, it does not mean that all family members will have it.

The average woman in the United States has about a 1 in 8, or a 12-13%, risk of developing breast cancer in her lifetime. Women who have an abnormal BRCA1 or BRCA2 gene (or both) can have up to an 80% risk of being diagnosed with breast cancer during their lifetimes. Breast cancers associated with an abnormal BRCA1 or BRCA2 gene tend to develop in younger women and occur more often in both breasts than cancers in women without these abnormal genes.

Women with an abnormal BRCA1 or BRCA2 gene also have an increased risk of developing ovarian, colon, pancreatic, and thyroid cancers, as well as melanoma.

Men who have an abnormal BRCA2 gene have a higher risk for breast cancer than men who don’t — about 8% by the time they’re 80 years old. This is about 80 times greater than average.

Men with an abnormal BRCA1 gene have a slightly higher risk of prostate cancer. Men with an abnormal BRCA2 gene are 7 times more likely than men without the abnormal gene to develop prostate cancer. Other cancer risks, such as cancer of the skin or digestive tract, also may be slightly higher in men with abnormal BRCA1 or BRCA2 genes.

Other genes
Changes in other genes are also associated with breast cancer. These abnormal genes are much less common and don’t seem to increase risk as much as abnormal BRCA1 and BRCA2 genes, which are considered rare. Still, because these genetic mutations are rarer, they haven’t been studied as much as the BRCA genes.

  • ATM: The ATM gene helps repair damaged DNA. DNA carries genetic information in cells. Inheriting two abnormal copies of this gene causes the disease ataxia-telangiectasia, a rare disease that affects brain development. Inheriting one abnormal ATM gene has been linked to an increased rate of breast cancer in some families because the abnormal gene stops the cells from repairing damaged DNA.
  • p53 (also called the TP53 gene): The p53 gene provides instructions to the body for making a protein that stops tumour growth. Inheriting an abnormal p53 gene causes Li-Fraumeni syndrome, a disorder that causes people to develop soft tissue cancers at a young age. People with this rare syndrome have a higher-than-average-risk of breast cancer and several other cancers, including leukemia, brain tumors, and sarcomas (cancer of the bones or connective tissue).
  • CHEK2: The CHEK2 gene also provides instructions for making a protein that stops tumour growth. Li-Fraumeni syndrome also can be caused by an inherited abnormal CHEK2 gene. Even when an abnormal CHEK2 gene doesn’t cause Li-Fraumeni syndrome, it can double breast cancer risk.
  • PTEN: The PTEN gene helps regulate cell growth. An abnormal PTEN gene causes Cowden syndrome, a rare disorder in which people have a higher risk of both benign (not cancer) and cancerous breast tumours, as well as growths in the digestive tract, thyroid, uterus, and ovaries.
  • CDH1: The CDH1 gene makes a protein that helps cells bind together to form tissue. An abnormal CDH1 gene causes a rare type of stomach cancer at an early age. Women with an abnormal CDH1 gene also have an increased risk of invasive lobular breast cancer.

If you have the BRCA 1 or BRCA 2 gene this opens the possibility for you of treatment by PARP inhibitors being pioneered by Professor Harris at the Churchill Hospital, Oxford. He has had very successful results. Essentially the PARP inhibitors prevent the cells from repairing themselves thus leading to apoptosis.

Parp Inhibitor

  • A parp also known as a Poly (ADP-ribose) polymerase is an enzyme which repairs damage done to our DNA. In basic terms a parp enzyme regulates our body repairing damaged DNA. In normal cells this is useful and stops cell death however Doctor de Bono and his colleagues have suggested that cancer cells may used the PARP repair method to their advantage.
  • A parp-1 inhibitor is a new drug which causes inhibition of parp function. Studies recently conducted have shown that this new parp drug is an inhibitor of cancer as it disrupts the chemotherapy resistance in cancer cells.
  • An inhibitor cancer drug is a new type of cancer treatment which is being developed by two companies. Currently the parp inhibitor clinical trials are featuring two parp drugs named Parp Inhibitor BSI 201 and Olaparib. Both of these parp inhibitors are in phase two trials and have been studied testing parp breast and parp ovarian cancer throughout the world.

Parp Inhibitors

  • Parp Inhibitors can be used for ovarian, breast and prostate cancer and generally target mutations in the BRCA1, BRCA2 and inhibitor azd2281. These drugs represent a new way to treat BRCA-associated cancers, with the parp inhibition having the potential to overwhelm cancer cells and whilst they are not a cure for cancer the inhibition for the body to produce parp, leads to the BRCA cancer cells unable to be repaired as they grow: ultimately leading to the cancer inhibition and not being able to grow.
  • The reason this drug is such a promising target is that it has demonstrated significant anti-tumour effects in several types of cancer and parp inhibition does not appear to be critical for normal non-cancerous cells, thus parp inhibitors have the potential to impair tumor growth without damaging the normal cells, and therefore causing less side effects for those that receive the inhibitor cancer treatment. If parp trials are successful this may be one of the most famous anti-cancer drugs.

Cancer immunotherapy is the use of the immune system to reject cancer. The main premise is stimulating the patient’s immune system to attack the malignant tumour cells that are responsible for the disease. This can be either through immunisation of the patient in which case the patient’s own immune system is trained to recognize tumour cells as targets to be destroyed, or through the administration of therapeutic antibodies as drugs, in which case the patient’s immune system is recruited to destroy tumour cells by the therapeutic antibodies. Cell based immunotherapy is another major entity of cancer immunotherapy. This involves immune cells such as the Natural killer Cells (NK cells), Lymphokine Activated killer cell(LAK), Cytotoxic T Lymphocytes(CTLs),

Dendritic Cells (DC), which are either activated in vivo by administering certain cytokines such as Interleukins or they are isolated, enriched and transfused to the patient to fight against cancer.

Immunotherapy is another laboratory based procedure. The principle is to either energise the body’s cells to combat cancer or to adversely affect the cancer cell by exploiting known weaknesses in the caner physiology. The most successful results have been demonstrated with dendritic cell therapy.

Dendritic cell therapy is currently being investigated at Southampton Hospital Southampton Experimental Cancer Medicine Centre (ECMC) but is available in Germany, Austria and Switzerland. The following information has some elements extracted from one of those clinics.

Growing evidence indicates that the uninhibited growth of cancer cells results from inappropriate surveillance and control of the immune response. Dendritic cell (DC) therapy based on the concept, that the body‘s own defence system (immune system) can effectively recognize and destroy cancer cells. By modification and programming the body‘s defence system to attack residual cancer cells expect to be the starting point of cancer metastases. In this way DC therapy is a complementary and supportative approach of current standard cancer therapy.

Dendritic cells are key cells for initiation of a cellular immune response The immune system is the body‘s natural defence system against disease. White blood cells, also known as leucocytes, are the effector cells of the immune system. Dendritic cells (DC) are a highly specialized subtype of white blood cells with a unique function. DC can pick up foreign cells or cell particles including cancer cells. Within the DC the cancer cells are destroyed and several pieces of the foreign material are displayed on the cell surface of DC. The exhibition of foreign material on the DC surface is recognized by other cellular effector cells that are then travelling through the body to recognize and destroy tumor cells displaying similar material as expressed by DC. In this way, DC “teach” the effector cells what type of cells are harmful for the body while the search and the destruction of tumor cells are mediated by specific killer cells.

DC therapy based on the finding that DC expressing tumour material of the patient‘s own cancer will introduce a strong immune response against the cancer cells. However, the number of circulating DC in the blood is extremely low which had hindered the clinical application of a DC therapy for a long time. Within the last decade new insights in the biology of DC together with new developments in biotechnology have opened the possibility for generation of DC outside the body. Starting from circulating white blood cells and employing specific culture conditions, it is now possible to generate large quantities of DC within the lab. This opens the possibility for a clinical application of DC immunotherapy as supportative treatment in cancer.


Micrometastases as a target for DC therapy
Micrometastases as a target for DC therapy. Micrometastases are single tumour cells or small tumour cell clusters shed by solid cancers and disseminated in various organs of the body. Tumour cell dissemination can occur during all stages of the disease, even before the diagnosis of cancer is set. Micrometastases are hard to diagnose, as even the newest diagnostic imaging methods cannot detect tumor cells at the single cell level. Micrometastases have a pronounced clinical impact. Single tumour cells can be the starting point of a recurrence of cancer, which can occur even 5 to 10 years after the
primary diagnosis.

Micrometastases are the ideal target for a DC therapy. DC therapy can destroy disseminatedcancer cells, thereby preventing the development of metastases, slowing the spread of thecancer, and help to extend the life expectancy.

Main targets for dendritic cell therapy include disseminated single tumour cells (micrometastases) or metastases of the following epithelial tumours:

    • breast cancer
    • ovarian cancer
    • prostate cancer

By activation of the body´s own immune system DC therapy is a complementary strategy for the treatment of cancer. According to the current knowledge, however, DC therapy is not a substitute for conventional treatment methods like surgery, chemotherapy, or radiotherapy.

The treatment protocol consists of three steps:
1) Collection of circulating leucocytes from the blood
2) Generation of DC
3) Injection of DC

The treatment protocol starts with the harvest of white blood cells from the circulating blood. Collection is performed using a specific type of machine (cell separator), a worldwide established method for cell harvesting from the circulating blood. A needle is placed in one arm, and your blood flows through a sterile, single use tubing set to the machine. Within the cell separator your blood is centrifuged. White blood cells are collected into a separate sterile bag while other blood cells and the fluid parts of the blood return to the body by a second needle placed to the other arm. Medical doctors and specific trained personal closely monitor the whole collection process.

After collection the white blood cells are taken to the laboratory where the cells are grown in specific culture medium under strictly controlled conditions. During the culture the cells convert to dendritic cells. At the end of the culture period DC are tested for their maturity, purity and sterility. DC are frozen in liquid nitrogen and are ready for reinfusion. Cell processing and maturation into DC is performed in a specialized lab unit. The whole culture process is performed and monitored by a team of experts with profound experience in the field of cellular biology and cell culture. The cellular production unit fulfil the national and EU regulatories for the production of cellular therapies.

Injection of the DC is performed every 3 to 4 weeks for up to nine months. To guarantee an optimal immune response, the injection is performed under the skin nearby a lymph nodule. At every cell injection DC-induced immune response against cancer cells is monitored by the analysis of your immune status using specific blood tests. Medical doctors with experience in the application of cellular immunotherapies perform the injection of DC. Injection of DC is generally well tolerated and is not associated with adverse side reactions. In some patients DC injection can lead to skin rash, fever, or flu-like symptoms. However, the appearances of symptoms are rather rare and normally disappeared within 2-3 days after the DC injection. In severe cases the symptoms can be controlled by antiphlogistic drugs.

Although this treatment is relatively new to cancer it has shown marked success with motor neurone disease and I have spoken personally with a lady who was unable to continue with chemotherapy but who after 9 weeks of a single administration of T cells has had fantastic success in that her tumour hasn’t grown or spread out of her lymph system.

Newcastle Disease Virus
Newcastle disease was discovered in Newcastle upon Tyne, England in 1926 (Doyle), but also at this time slightly different strains were found in other parts of the world.
Exposure of humans to infected birds (for example in poultry processing plants) can cause mild conjunctivitis and influenza-like symptoms, but the Newcastle disease virus (NDV) otherwise poses no hazard to human health. Interest in the use of NDV as an anticancer agent has arisen from the ability of NDV to selectively kill human tumour cells with limited toxicity to normal cells.

Newcastle disease virus (NDV) is a virus that is of interest because it replicates (makes copies of itself) more quickly in human cancer cells than in most normal human cells and because it can kill these host cells).

NDV can be used to directly kill cancer cells, or it can be given as a cancer vaccine. Cancer vaccines cause the body’s natural immune system to seek out and destroy cancer cells.

This treatment was combined for with dendritic cell therapy. The cells were primed with the virus and then injected back into me. NDV is unavailable in the UK.

 

NF- P2X7
Biosceptre’s technology is based on the discovery of what potentially could be the world’s first truly universal cancer marker/target – a non-functional cellular receptor (nf-P2X7) that is found on cancer cells but is never present on healthy cells. This breakthrough has prompted the development of a patented range of monoclonal, polyclonal and domain antibodies that target diseased cells whilst having no adverse effect on surrounding healthy cells. The technology is unique in its ability to target all forms of tumours tested to date (both solid and blood based tumours) and has the potential to radically change the way cancer is diagnosed and treated in humans and other mammals.

Novel Marker nf-P2X7
P2X7 is a major cellular receptor responsible for normal programmed cell death (apoptosis). At the time an aging cell is ready to die, P2X7 is expressed on the cell wall triggering a sequence of biological processes that leads to apoptosis. This process is so fast that, under normal circumstances, P2X7 cannot be detected on the cell wall.
Cancer cells have abnormal “death receptors” (nf-P2X7) on their surface and programmed cell death (apoptosis) does not occur. Biosceptre’s custom-made antibodies attach themselves to these abnormal receptors and this combination then appears to result in death of the cancer cells – perhaps by re-initiation of normal apoptosis, perhaps by another mechanism such as attracting lymphocytes and macrophages which are involved in killing cells. This is depicted in the figure below:

Universal Cancer Marker
Historically, the cancer markers discovered by researchers have usually been specific to only one or two forms of cancer. Through rigorous testing, Biosceptre has already confirmed the presence of nf-P2X7 in cancers of the prostate, breast, bowel, oesophagus, skin, lung, cervix, uterus, lymph nodes, ovaries, brain, stomach, bladder and other organs. These historic findings have been independently verified.
nf-P2X7 is highly specific and has been found in all cancers tested to date, providing an unprecedented, universal cancer marker and therapeutic target.

I have had Dendritic cell therapy where the cells have been primed with Newcastle disease virus and nf-P2X7 at a clinic in Germany. I do still currently have Dc therapy however, there can often be changes incorporating other drugs and treatments.

Zometa infusion and Gamma Delta cells

There is a treatment to enhance gamma-delta-T-cells in the body. These cells are unique to primates and represent a minority white cell in our blood. They expand dramatically in many acute infections and are supposed to be a key fighter in cancer as well having potent cytotoxic activity. Cancers are highly susceptible to gamma-delta T-cell mediated lysis which led to the proposal that gamma-delta T cells can be used for cancer immunotherapy (See Kabelitz D, Potential of human gammadelta T lymphocytes as immunotherapy for cancer, Int J Cancer 2004 Dec 10;112(5):727-32). Moreover, most interesting is the finding of efficient killing of cancer stem cells by gamma-delta T cells (Todaro M, et al. J Immunol. 2009 Jun 1;182(11):7287-96).

In fact there are some trials concerning gamma-delta-T-cells in treating cancer patients. Gamma-delta T-cells are known to be stimulated by a number of non-peptide phosphorylated antigens like bisphosphonates (e.g. Zometa) leading to increasing numbers of peripheral blood gamma-delta T-cells. Therefore by infusing a very low dose of Zometa, this stimulates the Gamma delta cells on one’s body and hopefully kills cancer.

Zoledronic acid( Zometa) belongs to a group of drugs called bisphosphonates. Bisphosphonates are commonly used to treat bone thinning (osteoporosis).

In certain situations, bisphosphonates can help protect your bones against some of the effects of secondary bone cancer, such as pain and bone weakness. Secondary bone cancer occurs when the original (primary) cancer spreads to form a new cancer (secondary cancer or metastasis) in the bone.

Zoledronic acid is often given alongside other cancer treatments. As well as being used for some types of secondary bone cancer, it has been shown to be effective for people with myeloma (a cancer of the plasma cells, which are a type of blood cell). It is also used to lower a raised calcium level in the blood.

So far Dr Nesselhut has had a high success rate whereby approximately 42% of his patients have actually gone into remission after having this treatment.

IMM101

IMM-101 has been provided by Immodulon Therapeutics, a drug research company focused on using naturally occurring microorganisms called mycobacteria in a range of important human diseases.
Immodulon’s lead product contains a specific microorganism called Mycobacterium obuense (often shortened to M. obuense and referred to as IMM-101). It is closely related to another organism called Mycobacterium vaccae (M. vaccae) which has previously been demonstrated to have a potentially beneficial effect in the treatment of certain types of cancers. IMM-101 is classified as an immunotherapy as it seeks to beneficially change the patient’s immune system.
IMM-101, which is not yet licensed for sale in any country, is currently being investigated in three therapeutic clinical trials to investigate its safety, tolerability and efficacy in the treatment of advanced pancreatic cancer (www.clinicaltrials.gov; NCT01303172) and advanced colorectal cancer (www.clinicaltrials.gov; NCT01539824). A phase I clinical trial in patients with advanced melanoma (a form of skin cancer) has been successfully completed and a long term follow-up study for surviving patients, initiated in 2012, is continuing to monitor for safety and tolerability of long-term IMM-101 administration.
IMM-101 is therefore an investigational product with unproven efficacy and limited safety and tolerability data. Initial work suggests that this product may have the potential to complement and be synergistic with established and emerging clinical therapies in cancer.

Why Use Mycobacteria?
Mycobacteria are a family (or genus) of bacteria which are grouped together because of their specific characteristics. A small number of mycobacteria are associated with human disease such as tuberculosis and leprosy. However, the majority of mycobacteria are harmless and are encountered extensively in the environment. It is these harmless mycobacteria and not those associated with diseases that are of interest as potential medicines. The reason for using these mycobacteria for the treatment of cancer is based on historical observations that suggest that they may have a beneficial effect.
For a long time doctors suspected that the immune system had an effect on certain cancers. Even before the immune system was well understood, William Coley, MD, a New York surgeon, first noted that getting an infection after surgery seemed to help some cancer patients. In the late 1800s, he began treating cancer patients by infecting them with certain kinds of bacteria, which came to be known as Coley toxins. Although he had some success, his technique was overshadowed when other forms of cancer treatment, such as radiation and chemotherapy, came into use. Bacillus Calmette-Guérin (commonly known as BCG) is a vaccine prepared from a strain of Mycobacterium bovis which is used to protect against tuberculosis. During clinical studies, BCG was also found to have positive effects on certain patients with lung cancer and malignant melanoma. BCG is still used today to treat superficial bladder cancer where it has a very good effect.
M. obuense has been selected for clinical development based on historical work performed using another very closely related mycobacterium (M. vaccae) which was originally tested as a treatment for tuberculosis and leprosy. Unexpectedly, it was found that a small number of those patients who were treated showed an improvement in malignancies from which they were also suffering at the time. This led to M. vaccae being studied for its effects in a number of preliminary trials in certain types of cancers – where it was demonstrated to have potentially beneficial effects in some patients.

What is IMM-101 (Mycobacterium obuense) and how does it work?
IMM-101 contains a specific organism (Mycobacterium obuense) which has been killed at high temperature so that it is not infectious but still retains the ability to produce immunological effects that may be beneficial to you.
Many cancers are believed to develop as a result of a malfunction of the body’s immune responses, allowing the cancer cells not only to survive, but also to grow unchecked. IMM-101 has been shown to influence the function of certain cells of the immune system which may provide beneficial effects by encouraging the body’s immune system to attack the cancer.

I was lucky enough to have this treatment combined with microwave ablation on two lesions in my right lung through Professor Dalgliesh. The idea was that it should enable an immune response and that once the ablation blasted the tumours the immunity would start searching for cancer cells and kill the rest of the tumours.

Each injection is given in the upper arm starting once every two weeks for the first three weeks, then reducing down to once a month then once every two months.

It is a very small amount that is used and initially I experienced only a tiny red lump like an insect bite which evolved into quite large open pusy sites. They do leave small red scars but everyone is different and I have been advised some people didn’t get any open sores. I have also been told when they do react in such a violent way that this is a good sign the immunity is responding.

Nivolumab and ipilimumab

 

Since 2015  there have been some remarkable research and trials using nivolumab and ipilimumab.

I have been using nivolumab and ipilimumab in small doses administered by Dr Nesselhut in Germany for 12 months. It is helping stop any new cancer from growing. That combined with treatments I have been having at Prof Vogl’s in Frankfurt give it a double whammy effect.

Nivolumab is an immunotherapy that is combined with other drugs to treat melanoma, but indications are that it may also be effective for other cancers involving the lungs and kidneys. It is a human IgG4 anti-PD-1 monoclonal antibody. It acts as an immunomodulatory by blocking ligand activation of the programmed cell death 1 (PD-1) receptor on activated T cells.

Ipilimumab is usually combined with nivolumab in small doses. It works by attaching itself to normal immune cells. This changes the way these cells work and helps the immune system destroy cancer cells.

They do come with side effects and can cause auto immune disease. Anything from skin rashes, bowel problems, breathlessness and more. I have so far not really experienced any to date.

For me, I haven’t experienced complete remission but apart from my right lung the rest of the tumours throughout my body have either remained stable or remitted. I still believe this is a very good option.

Cancer cells are particularly adversely affected by heat. We have found some treatments that takes advantage of this weakness.

Radiofrequency ablation 
This information is about radiofrequency ablation (RFA). RFA is a treatment that is used for some types of cancer.

How RFA works 
RFA uses heat to destroy cancer cells. It uses a probe called an electrode to apply an electrical current (radiofrequency) to a tumour. The electrical current heats the cancer cells to high temperatures, which completely destroys (ablates) them. The cancer cells die and the area that’s been treated gradually shrinks and becomes scar tissue.
RFA doesn’t always manage to destroy all the cancer cells. Some people may need to be treated more than once. RFA can be repeated if the tumour starts to grow again.

How it is given
RFA can be given:

  • by placing one or more needle-like electrodes through the skin percutaneously) into the tumour – this is the most common method
  • by making a small cut in the skin and passing the electrodes through a mini-telescope (laparoscope) into the tummy area
  • at the same time as an operation to remove some of the tumour.

What usually happens 
On the day of your treatment you’ll be asked not to eat anything for several hours beforehand. If you take any medicines, you’ll usually be asked to take them as normal. If you take drugs that can thin your blood, such as aspirin or warfarin, your doctor will give you instructions about when to stop taking these.

The treatment usually takes place in the operating theatre or hospital scanning department. Treatment takes about 1–3 hours, depending on the size and number of tumours being treated. It’s possible to have it as an outpatient, but most people will stay overnight in hospital. If you’re having the treatment as an outpatient, you’ll need to arrange for someone to take you home, as you won’t be able to drive for 24 hours afterwards.

Before the treatment you’ll see a doctor who will explain the procedure. This is a good time to ask questions if you’re unsure about anything. You will then be asked to sign a form to say that you agree (consent) to the treatment.
A nurse will give you a hospital gown to change into, and a doctor or nurse will place a fine tube (cannula) into a vein in your arm or on the back of your hand. You may also have blood samples taken to check your general health and blood clotting.
RFA can be given with a local anaesthetic to numb the area and a sedative to make you drowsy. If you need to have a larger area treated, RFA is usually done under a general anaesthetic.
Once you’re in position on the treatment couch and have had the anaesthetic, you’ll have an ultrasound scan (uses sound waves to look inside the body) or a CT scan (takes x-rays that give a 3D picture of the inside of the body). These scans help the doctor guide the electrode into the right position and keep a close eye on what’s happening during your treatment.

Once it’s in the right position, the electrical current is passed through the electrode to the tip. How long the current is applied for will depend on the size of the tumours.
An area of healthy tissue around the tumour is usually also treated, as there may be cancer cells around the tumour that can’t be seen. The treated tissue is not removed, but it slowly shrinks and heals over time.
If you have a larger tumour or more than one, the doctor may need to use a number of electrodes.

When RFA can be used
RFA can be used to try to cure a cancer, reduce its size or relieve symptoms (palliative treatment). It can be given alone or with other cancer treatments.
RFA may be used when surgery is not possible. This may be if:

  • someone has other medical conditions that mean they’re not fit enough to have a general anaesthetic
  • the tumour is near an important body structure or major blood vessel.

RFA is mainly used to treat:

  • liver cancer that has started in the liver (primary) or a cancer that has spread to the liver from another part of the body (secondary)
  • lung cancer that has started in the lung (primary) or a cancer that has spread to the lung from another part of the body (secondary)
  • kidney cancer.
I have also experienced Microwave ablatation. This very similar to the process of radiofrequency ablation, but it wasn’t available here for me so I had it with Prof Vogl in Frankfurt, Germany. I remained awake throughout and left the hospital that day. I did experience a period of recovery at home, but my side effects were short lived and so far the results are looking really good.

We will continue to research any treatments that use heat to fight cancer.

The Oncothermia method (EHY 2000)
I have personally had this treatment at the ‘Institute fur Tumortherapie’ in Germany.
Oncothermia, i.e. the loco-regional deep electro-hyperthermia system using the EHY-2000 device, is a fast developing supportive, complementary treatment method against tumours. The principles are based on the classical method of hyperthermia, but the aim, beside the absolute increase in temperature, is especially the direct electric field energy absorption in the extracellular liquid, and numerous chemotherapies. Furthermore, it leads to an increased immunogenicity and effectively reduces the pain of the patient.

Mechanism
Oncothermia is particularly suitable for the combination with other oncological methods. In combination with radio and/ or chemotherapy. Oncothermia has different nodes of action with both its own and synergistic effects;
Thermal damage of tumour cells
Acidic poisoning of malignant tissue
Inhibitation of repair mechanism
Potentiation of chemo/radiotherapy, immunotherapy and NDV (Newcastle Disease Virus)
Stimulation of the immune system

Characteristics
Non invasive treatment
Focuses’ automatically on tumour tissue
Painless and free of side effects
Significant gain of life quality

Technical details
The method transfers energy using the principle of capacitive coupling, like a condenser, of radio waves of 13,56 MHz, where no external shielding is needed. Oncothermia utilises the special absorption rate of the near membrane extracellular liquid of the tumour. The tumour tissue has lower impedance than the surrounding tissue, so most of the energy is transmitted and absorbed by the cancer lesions. This selection of the tumour tissues (self focusing) renders external focussing unnecessary.


FIR Infrared
FIR Infrared is most commonly known for the sauna or treatment for isolated treatment suing a lamp. Far Infrared rays are waves of energy, totally invisible to the naked eye, capable of penetrating deep into the human body, where they gently elevate the body’s surface temperature and activate major bodily functions.

Benefits
Far Infrared expands capillaries which stimulates increased blood flow, regeneration, circulation and oxygenation. It is excellent for detoxing. Scientists in Japan report that in the FIR treatment of clogged capillary vessels, heat expands the capillaries and then initiates the start of a process to dissolve hidden toxins. Far Infrared thereby promotes elimination of fats, chemicals and toxins from the blood: Poisons, carcinogenic heavy metals – toxic substances from food processing – lactic acid, free fatty acids, and subcutaneous fat associated with aging and fatigue – excess sodium associated with hypertension – and uric acid which causes pain. Far Infrared also stimulates enzyme activity and metabolism – One hour under a lamp improves metabolism.
It promotes rebuilding of injured tissue by having a positive effect on the fibroblasts (connective tissue cells necessary for the repair of injury). Furthermore, it increases growth of cells, DNA syntheses, and protein synthesis all necessary during tissue repair and regeneration. Excellent for healing burns, scar tissue and skin problems.

Far Infrared strengthens the immune system by stimulating increased production of white blood cells (leukocytes) by the bone marrow and killer T-cells by the thymus. Far Infrared strengthens the cardiovascular system by causing heart rate and cardiac output increase, and diastolic blood pressure decrease – Extensive research by NASA in the early 1980’s led to the conclusion that far infrared stimulation of cardiovascular function would be the ideal way to maintain cardiovascular conditioning in American astronauts during long space flight.

FIR and cancer
Cancerous cells cannot exist if blood circulation is smooth and continuous.
A cancerous cell has to stop moving to proliferate. The cancerous cell’s positioning, or settling down, is directly related to the capillaries, which are at the end of the blood vessels. The cancer cell tries to position itself by going through the capillary. If it goes through, there could be no settling down or positioning of the cancer cell – which is what happens if there is good blood circulation. If the cancer cell fails to pass through the capillary because of some functional disorder in the circulation, the cell could easily position itself. Good blood circulation of the capillaries – without functional disorder – leaves no way for the cancerous cell to settle down and position itself. The cell will then be killed by the immunocyte (the immunity cell).

The cancerous cell has a weakness, heat. It will die if the temperature goes above 42C/107.6 F. Far Infrared treatment raises body temperature to 42 degrees C. Therefore heat enables capillaries to expand, thus enabling good circulation and combating the potential existence of cancer cells.

Around the world there are many different treatments some laboratory based, some traditional and some spiritual that fall outside of main stream medicine. This fact does not mean they do not work. They just don’t work in the same way as traditional western medicine as they have demonstrated that they do combat cancer. As such these must be included in the Ten Point Plan. Our list here is not all encompassing but centres on the treatments that we have discovered and produced the most successful results. A big word of warning here we found ourselves wanting to believe what we have read and this area has been hugely exploited by sometimes well meaning sometimes fraudulent individuals with no expertise or back ground in any medical field. Please be extremely cautious, work on recommendation and don’t part with any money in advance of treatment.

Acupuncture
Acupuncture is an excellent healing modality for every aspect of cancer. Today, many people think of acupuncture for relieving back pain, quitting smoking, or easing nausea from chemotherapy. But there are many ways that acupuncture can play a key role in recovery from cancer, regardless of the course of medical treatment.

The period of time following breast cancer treatment is one of significant transition. Women are coming to the end of an extremely challenging time and often want to integrate positive self-care, such as healthy diet, exercise, and meditation. Acupuncture is an outstanding choice for healing during this time since it works on the level of the body, mind, and spirit. Many acupuncturists can make recommendations about these changes and also provide exceptional emotional support.

Traditional Chinese acupuncture is based on the theory that vital energy called Qi circulates around the body along channels called meridians. Blockages in the flow of Qi are thought to cause ill health. Blockages may occur when we are

  • Anxious or stressed
  • Angry
  • Frightened
  • Not eating properly
  • Suffering from an infection
  • In poor health due to illness or disease
  • Exposed to substances that might harm our health

Traditional acupuncture aims to correct the flow of Qi. In traditional Chinese medicine acupuncture is used alongside diet and herbal medicine.

I have experienced this treatment and look to continue having it on a regular basis. It helps with boosting the immunity, boosting my energy levels, relieving stress and calming my spirit.

 

Photodynamic Therapy or PDT
PDT uses laser or other light sources, combined with a light-sensitive drug (sometimes called a photosensitising agent) to destroy cancer cells.

A photosensitising agent is a drug that makes cells more sensitive to light. The drug is attracted to cancer cells. It does not become active until it is exposed to a particular type of light. When the light is directed at the area of the cancer, the drug is activated and the cancer cells are destroyed. Some healthy, normal cells in the body will also be affected by PDT, but these cells will usually heal after the treatment.

When it is used 
PDT can be used to treat some cancers or conditions that may develop into a cancer if not treated (precancerous). It is used when the affected area, or the cancer, is on or near the lining of internal organs. This is usually with cancers or conditions that affect the:

  • bile duct and gall bladder
  • gullet (oesophagus)
  • head and neck
  • lung
  • mouth
  • skin (but not melanoma).

Researchers are trying to identify the types of cancer PDT is most effective for. Trials are also looking at new photosensitising agents, new laser and non-laser light treatments, and ways of reducing the side effects. You may be offered PDT as part of a trial.

Cancer and PDT
In cancers that are being treated at an early stage, the aim of PDT treatment is to try to cure the cancer. With more advanced cancers, the aim of PDT is to shrink the cancer and reduce symptoms.

How it is given
The treatment is normally given in two stages:

Stage 1
The first stage of treatment involves giving a light-sensitive drug.
For cancers of the skin, the drug is usually applied to the skin as a cream. For cancers that are inside the body, the drug may be given as a drink or more usually as an injection into a vein (intravenously).
There is a delay between the drug being given, or the cream being applied, and the next stage of treatment. This allows time for the drug to concentrate in the cancer cells. The length of time you need to wait for treatment after having the drug can vary from hours to days.
There are several drugs that can be used as the photosensitising agent. The most common are 5-aminolevulinic acid (ALA), temoporfin (Foscan®) and porfimer sodium (Photofrin®). The drug used will depend on the type of cancer you have and which is best for your situation. Your doctor or nurse will explain which drug will be used and how it will be given.

Stage 2
The second stage of treatment involves shining a laser or sometimes a non-laser light directly on to the cancer.
For skin cancers, the light is shone directly on to the skin.
For internal cancers, a flexible tube (endoscope) may need to be passed into your body to deliver the light to the tumour. Depending on where the cancer is in the body, a scan or ultrasound may be used to help direct the laser light to the tumour.

Possible side effects

As with all kinds of treatment, the experience of PDT can vary from person to person. How the treatment is given and the side effects it may cause vary according to:

  • the area of the body being treated
  • the type of photosensitising drug given
  • the amount of time between giving the drug and applying the light
  • the amount of skin sensitivity to light following treatment.

Airnergy
Airnergy technology uses one of nature’s processes which has existed for millions of years, i.e. photosynthesis in green leaves.

This ensures that oxygen is activated in a way which your body understands.
Similar to water, warm or cold, oxygen also has various properties. Warm water dissolves materials such as sugar or salt crystals quickly and in larger quantities because warm water is highly reactive. Cold water only dissolves such materials at a slow rate and in smaller quantities because cold water has low reactivity.

Oxygen also has various properties: the oxygen present in respiratory air is not reactive. In order to make the oxygen utilisable for producing energy in the body, the body must first bring the oxygen into its reactive state – the singlet state. However, as the body’s ability to use the oxygen diminishes with increasing age, through stress, illness and environmental toxins the body requires energy in order to improve its performance and therefore its healing and regeneration processes again. Airnergy helps the body to increase its use of oxygen in a natural way.

In the Airnergy device the air’s oxygen is continually returned to its high energy state (singlet oxygen) which is the physiologically active form of the oxygen that the body is familiar with. This enables a patent-protected process to take place which is technologically adapted from the natural processes of photosynthesis.

The short-lived singlet oxygen returns in a fraction of a millisecond to its basic state and therefore gives off energy. The water molecules in the respiratory air take over this energy which is then inhaled through a comfortable breathing mask together with normal respiratory air.

In the organism the “Airnergy energy“ noticeably improves the way the oxygen is used and has a positive effect on many of the body’s functions – without an additional supply of oxygen and without foreign substances.

The AIRNERGY Oxygen Therapy device is a portable, compact machine for use in the home and clinic that creates ‘Energised Air’.

 

Reflexology
Reflexology has been used for centuries. It is thought to have been developed originally by the ancient Egyptians. It is one of the most popular types of complementary therapies in the UK among people with cancer.

Reflexology means applying pressure and massage to areas on your feet and hands. The feet are the most common area to treat. According to reflexologists, you have ‘reflex areas’ in your feet that match every part of your body. Therapists claim that there is a map of the left side of your body on your left foot, and the right side of your body on your right foot. For example, your left big toe represents the left side of your head, and a point around the ball of your right foot represents your right lung. These maps can vary a little between different branches of reflexology.

Reflexology can really assist with patients who undergoing cancer treatment to relieve symptoms, ease stress and leave you feeling tranquil. I personally think reflexology can actually work to heal the body and create harmony.

 

Natural Healing

Reiki is the name given to a system of natural healing which evolved in Japan from the experience and dedication of Dr Mikao Usui (d. 1926). Fired by a burning question, Dr Usui was inspired to develop this healing system from ancient teachings after many years of study, research and meditation. He spent the rest of his life practising and teaching Reiki. Today Reiki continues to be taught by Reiki Masters who have trained in the tradition passed down from Master to student.

There is no belief system attached to Reiki so anyone can receive or learn to give a Reiki treatment, the only prerequisite is the desire to be healed.

A Reiki Treatment

The method of receiving a Reiki treatment from a practitioner is a very simple process. The recipient simply lies on a couch and relaxes. If they are unable to lie down the treatment can be given in a sitting position, the main thing is for the recipient to be as comfortable as possible. There is no need to remove any clothing as Reiki will pass through anything, even plaster casts. The practitioner gently places their hands non-intrusively in a sequence of positions which cover the whole body. The whole person is treated rather than specific symptoms. A full treatment usually takes 1 to 1½ hours with each position held for several minutes.

Which conditions can Reiki help?

It is possible to heal at any level of being: physical, mental, emotional or spiritual. Acute injuries can be helped to heal very quickly but more chronic illness takes longer. In some cases such as terminal illness, there is not enough time for the progress of the disease to be reversed. However, in such cases there is usually great benefit and enhancement of the quality of life giving a sense of peace and acceptance during the time remaining.

Reiki healing can be given anywhere at any time as no special equipment is needed. The practitioner is a channel which the energy is drawn through by the need or imbalance in the recipient. Neither person has to use any effort of will or concentration during this process.

As running water smoothes the jagged edges of a rock until it is small enough to roll away, Reiki flows to the areas of need, soothing pain and supporting the body’s natural ability to heal itself. Reiki restores balance in one’s life.

Reiki supports all forms of treatment both orthodox and complementary.

 

Essential Treatments

There are a number of treatments that I believe are essential in the well being for someone living with canSer which helps on a physical, mental and emotional level. The biggest issue when being a canSer survivor or even living with someone with canSer is the fear of getting ill and dying. A lot of what haunts an individual is made up in our minds. Retraining ourselves and old habits is very hard and I recommend seeking the assistance of a trained therapist in helping remove unnecessary fears and worries so that you can live a full and positive life without a fear of the future because now is more important than tomorrow or yesterday.

Make Permanent Changes

Why is it we get stuck with negative states, emotions and habits anyway?
The reason permanent change is so difficult if not tackled in the right way, is that we have built up the negative patterns over an extended time…certainly months, if not years. These patterns are coded not only in the mind, but through chemical reactions also through the body. When you think about it all emotions have a feeling. Take fear or anxiety for example: we can actually feel the cortisol and noradrenalin (in excess levels…both poisons by the way!) coursing through our body because we’re on “red alert”. Well, guilt or shame have a similar chemical reaction, albeit using different chemicals to create the particular feeling for the shame or the guilt.

The more we fire off these chemical reactions (i.e. the more often we become anxious) through the mind and the body, the more addicted the body becomes to these chemicals and the easier it is to fire off the fearful or anxious neural pathways, until the point it becomes habitual and the slightest thing sets off the anxiety… “did I put the bins out last night?…will I get into trouble from the neighbours if my rubbish starts to spill over?…what happens if they report me?…I read about that woman in the paper recently who was put into prison for the mess she made of the street she lived in” etc.

We spiral off out of control seemingly without any ability to remain in reality; in fact, the worse the anxiety (stress or depression) gets, the more difficult it becomes for the mind to know what is real and what is pure fantasy!

In order to make permanent changes, we need to release the negative programming, patterns and pathways from the past and build new, more desirable ones.

There are 3 ways to make permanent emotional or habitual changes:

Counselling

Counselling primarily uses the conscious mind to think through logically and rationally the client’s issue: where it has come from and how it is affecting their life currently. Relatively little time is spent creating a new future…which is, of course, the client’s sole interest. Unfortunately this involves months or often even years of trawling through traumatic times from the past and confronting how powerless the client feels in their current situation. Gradually, over an extended period of time, with the assistance of a good therapist, the Mind will create the necessary new neural pathways and therefore the changes.

Visualisation

Visualisation, or Mental Rehearsal as it is sometimes referred to, means spending time regularly in a relaxed (you might say in semi-trance) state and imagining your new life with the change already made. Regular repetition will grow new neural pathways and create the changes you want.

However, this takes real determination and persistence, because you are “on your own” and you have got to make the new neural pathways stronger than the “bad ones”, which you’ve probably had for years; visualisation should therefore be done religiously for an hour a day over a month.

The problem here is, that whilst Counselling seems to spend all of the time in the past, Visualisation doesn’t do anything to actively change the way the mind sees what happened in the past and relies solely on creating new neural pathways to overpower the old unwanted ones.

Neural Recoding

Neural recoding is unique mix of strategies taken from NLP, Hypnotherapy and Coaching. Neural Recoding is a process of releasing the emotional and habitual pain from the past and then creating a new and more desirable future. Because Neural Recoding involves a clear conscious understanding of how we have created our old undesired reality, the unconscious mind is already primed to make the desired changes even before the creation of new neural pathways. Neural Recoding is a unique therapy modality born out of the experience of 10 years of 1-2-1 sessions with thousands of clients and many months and many £000’s worth of training in different behavioural and brain disciplines by a therapist called Mark Newey. His details are on the resources page. I have personally been to see him and feel I have overcome many issues mainly my fear of death and illness.

Hypnosis

Hypnotherapy is a completely natural, safe and effective way to treat a wide variety of difficulties. Best known for helping people stop smoking, lose weight and relax – it can also aid many aspects of emotional and physical health. Additionally, more and more people are using hypnotherapy for personal development, performance enhancement, and general well-being.

 

Coffee Enema

Why in the world would someone use coffee in an enema?

Enemas are an ancient form of hydrotherapy. Enemas have been around since the dawn of time and have even been recorded in biblical scripts. They have been used for hundreds of years for mechanically cleansing the colon. Enemas and colonic irrigation used to be routine procedures in hospitals. There are many types of enemas used for varying purposes. Coffee enemas were first popularized by Max Gerson, MD. Dr. Gerson pioneered nutritional therapy for cancer and other diseases with excellent results. His therapy combined coffee enemas with a special diet, juices and other supplements. The enemas were an integral part of the therapy.

Benefits

Here is a short list of the many benefits of coffee enemas:

Toxin elimination – The major benefit of the coffee enema, he said, is to enhance elimination of toxins through the liver. Indeed, endoscopic studies confirm they increase bile output. A patient was given a coffee enema while an endoscope monitored the entrance to the common bile duct. Within minutes of administering the enema, bile flow increased. Increased bile flow also alkalinizes the small intestine and promotes improved digestion.

Detoxifier – Coffee enemas are powerful detoxifiers, due to some amazing compounds within the coffee that stimulate the liver to produce Glutathione S transferase, a chemical which is known to be the master detoxifier in our bodies.

Cleansing – Coffee also acts as an astringent in the large intestine, helping clean the colon walls. A common contributor to ill health is the production and absorption of toxins within the small and large intestines. If food is not digested properly, sugars ferment and protein putrefies or rots. Both processes generate toxic chemicals which are then absorbed into the liver.

Stimulates Bile Flow – The coffee enema enhances digestion by increasing bile flow and removes toxins in the large intestine so they will not be absorbed. Most people with health complaints suffer from impaired digestion and production of toxic substances in the intestines.

Stimulates Liver – Coffee enemas are particularly helpful for slow oxidizers. Their liver activity is more sluggish and digestion is usually impaired. Fast oxidizers may have more difficulty retaining the enema.

How often?

Dr. Gerson recommended the coffee enema up to 6 times daily for severely ill cancer patients. His patients continued them for up to several years with no ill effects. I personally have one enema per day to assist detoxification or to enhance liver activity. Two enemas daily may be taken during a healing reaction if needed.

How to do a coffee enema

First off you will need to purchase an enema kit. I bought mine from Amazon. Buy organic ground coffee. I personally buy mine from Coffee UK and it is specifically used for enemas:

http://www.coffee.uk.com

  • Bring 500 ml of water to the boil. When it has boiled, take it off the hob an add 3 tablespoons of coffee. Place it back on the hob and boil for 3 minutes and then let simmer for 15 minutes.
  • Once simmered, remove from the hob and strain the liquid until no coffee granules remain in the liquid.
  • Into your enema kit (ensuring the enema tap is closed), pour approx 250ml coffee into the bag and top up with approx 500ml of pure water. (I tend to top up to just under a litre but only do this once you have tried it a few times as you may find it tricky to take.)
  • Get comfy in your bathroom. I lie on a towel or yoga mat on the floor hang the enema bag on a hook in my shower. I get my iphone or a book and a pillow and get cosy!
  • Turn the tap on the enema bag to make sure the coffee is running out okay. Close the tap again. Lie on your right hand side, pop the tube up your bottom, turn the tap to open and let the solution drain from the bag. Once there’s no solution left in the bag, turn the tap off and take it out.
  • Lie comfortably for 10-15 minutes or for as long as possible and then sit on the toilet to release.

New developments can be categorised into two sections; drug based and laboratory based.
And then from this point they can be further categorised into trial therapies or available therapies which they fit into is also affected by where you live in the world. We are looking at the perspective of the NHS in the UK.

Monoclonal antibodies

The newest development are monoclonal antibodies. My Oncologist put me on a drug that I administer myself once per month by injection into my stomach to stop any more tumours arising in my bones. It is called denosumab. It is a monoclonal antibody. Anything that ends in MAB is one.

Monoclonal antibody drugs are a relatively new innovation in cancer treatment. While several monoclonal antibody drugs are available for treating certain cancers.

What is a monoclonal antibody?

A monoclonal antibody is a laboratory-produced molecule that’s carefully engineered to attach to specific defects in your cancer cells. Monoclonal antibodies mimic the antibodies your body naturally produces as part of your immune system’s response to germs, vaccines and other invaders.

How do monoclonal antibody drugs work?

When a monoclonal antibody attaches to a cancer cell, it can:

Make the cancer cell more visible to the immune system. The immune system attacks foreign invaders in your body, but it doesn’t always recognize cancer cells as enemies. A monoclonal antibody can be directed to attach to certain parts of a cancer cell. In this way, the antibody marks the cancer cell and makes it easier for the immune system to find

Block growth signals. Chemicals called growth factors attach to receptors on the surface of normal cells and cancer cells, signaling the cells to grow. Certain cancer cells make extra copies of the growth factor receptor.

Extra growth factor receptors allow cancer cells to grow faster than the normal cells. Monoclonal antibodies can block these receptors and prevent the growth signal from getting through

Stop new blood vessels from forming. Cancer cells rely on blood vessels to bring them the oxygen and nutrients they need to grow. To attract blood vessels, cancer cells send out growth signals.

Monoclonal antibodies that block these growth signals may help prevent a tumor from developing a blood supply so that it remains small. Or in the case of a tumor with an already-established network of blood vessels, blocking the growth signals could cause the blood vessels to die and the tumor to shrink.

The monoclonal antibody bevacizumab (Avastin) targets a growth signal called vascular endothelial growth factor (VEGF) that cancer cells send out to attract new blood vessels. Bevacizumab intercepts a tumor’s VEGF signals and stops them from connecting with their targets.

Deliver radiation to cancer cells. By combining a radioactive particle with a monoclonal antibody, doctors can deliver radiation directly to the cancer cells. This way, most of the surrounding healthy cells aren’t damaged.

Radiation-linked monoclonal antibodies deliver a low level of radiation over a longer period of time, which researchers believe is as effective as the more conventional high-dose external beam radiation.

Deliver chemotherapy to cancer cells. By combining chemotherapy drugs with a monoclonal antibody, doctors can deliver chemotherapy directly to the cancer cells.

Ado-trastuzumab emtansine (Kadcyla) is one such drug approved to treat HER2-positive breast cancer. Ado-trastuzumab emtansine contains an antibody that attaches to the HER2 receptors on the breast cancer cells. The cancer cells then ingest the antibody, which releases a few molecules of chemotherapy.

The chemotherapy only damages the cancer cells, leaving the surrounding healthy cells undamaged.

Nivolumab and ipilimumab

I have been using nivolumab and ipilimumab in small doses administered by Dr Nesselhut in Germany. It is helping stop any new cancer from growing. That combined with treatments I have been having at Prof Vogl’s in Frankfurt give it a double whammy effect.

Nivolumab is an immunotherapy that is combined with other drugs to treat melanoma, but indications are that it may also be effective for other cancers involving the lungs and kidneys. It is a human IgG4 anti-PD-1 monoclonal antibody. It acts as an immunomodulatory by blocking ligand activation of the programmed cell death 1 (PD-1) receptor on activated T cells.

Ipilimumab is usually combined with nivolumab in small doses. It works by attaching itself to normal immune cells. This changes the way these cells work and helps the immune system destroy cancer cells.

They do come with side effects and can cause auto immune disease. Anything from skin rashes, bowel problems, breathlessness and more. I have so far not really experienced any to date.

Carboplatin

New developments in drug therapy are being led by the advancements of Cisplatin which is now available in second generation as Carboplatin.

www.carboplatin.org

Carboplatin is a chemotherapy drug used for treatment of many types of cancer. The U.S. Food and Drug Administration approved carboplatin for use treating patients with ovarian and non-small cell lung cancer, and oncologists often use Carboplatin “off-label” for other cancers. Testicular, stomach, and bladder cancers are among those treated with Carboplatin, as well as other carcinomas.
Carboplatin is one of the most widely used chemotherapy medicines. Often given to a patient as part of a combination regiment of two or more drugs, Carboplatin has established itself as an invaluable tool in the toolbox.

What is this chemotherapy agent?

Carboplatin kills cancer cells by binding to DNA and interfering with the cell’s repair mechanism, which eventually leads to cell death. It is classified as an alkylating agents. (Alkylating agents can be used for most types of cancer, but are usually considered of greatest value in treating slow-growing cancers.) The platinum agents form strong chemical bonds with thiol sulfurs and amino nitrogens in proteins and nucleic acids.

Carboplatin is sometimes called a “second generation” platinum drug. The first generation consisted of the drug Cisplatin, which came to prominence in the 1970s. Carboplatin was designed and planned as an improvement – a drug that worked in largely the same way with the same chemical mechanism, but with better biochemical properties that would not produce such nasty side effects. The idea was that with a lesser side effect profile, higher dosages could be given and the “pow” to the cancer cells could be increased.

Carboplatin differs chemically from Cisplatin by being a bigger molecule, with a dicarboxylate ligand. This slows the metabolic breakdown of the agent (it stays in the body longer) and reduces the rate of formation of toxic by-products.

Carboplatin is often used as part of a combination chemotherapy regimen. This means other chemotherapy medicines are given to the patient at the same time (same day). There are many advantages to the multi-pronged attack on cancer. The drugs can attack the cancerous cells at different phases of the reproductive cycle. And the combination allows the oncologist to work around limiting side effect issues.

The side effects of chemotherapy drugs are frequently what set the maximum dose. Even it is desirable to give more medicine to fight the cancer, the body cannot handle the increased load. These are cases where the therapeutic window is too narrow. By giving the patient a second drug which has side effects on different organ systems, the total chemotherapy dose can be increased without exceeding the maximum on any individual drug.

Combination chemotherapy is so common that medical best practices incorporate them into standard regimens. Carboplatin is often combined with Paclitaxel (Taxol), Doxyrubincin, or anthracycline agents. While a 2-drug combination is most common, there are others. A 4-drug regimen of Carboplatin, Paclitxel, Cetuximab, and Bevacizumab was recently reported to show good results against lung cancer.

Carboplatin is a major tool in the oncologist’s list of weapons against cancer.

Health care workers, including hospital technicians and nurses, have to be careful around Carboplatin and treat it as a hazardous material. In addition to being a medicine to stop cancer’s growth, it is also a carcinogen – it can cause cancer, too.

Another good thing about Carboplatin, compared to some of the new drugs, is that is off-patent and therefore cheap. With new targeted therapy drugs going for 50K/six-week regimen and Carboplatin coming in at under 2K, the cost difference is striking.

Carboplatin is a platinum organic compound. Plain Carboplatin appears as white crystals or powder, but it is mixed into a saline solution and administered through an intravenous feed. The feed tube is called a cannula, and patients usually receive the medicine over a 30 to 60 minute time period.

Dipyridamole

Dipyridamole is a harmless widely-used drug in treating patients who have survived an episode of thrombotic stroke or coronary thrombosis that has a vast potential of being a harmless anti-cancer drug. It belongs to a class of drugs known as platelet inhibitors. It helps to keep blood flowing by stopping platelets from clumping together and by keeping heart blood vessels open. It is hypothesized that dipyridamole inhibits cancer metastases by inhibiting tumour cell attachment to the vascular lining.

A report stated in the Lancet in the March 23, 1985 issue, p. 693, by E.H. Rhodes et al. of St. Hileir and Kingman Hospital in Surrey, England. These doctors for the past 11 years had been maintaining melanoma patients with Clark’s level IV and III disease on dipyridamole, 300 mg a day. Thirty of these patients were maintained on this dose of dipyridamole. Of them, 26 had level IV disease and four had level III disease. At five years, the survival of the level IV patients was 74%. The five-year survival for the total of the 30 of level IV and III disease was 77%. None of the level III patients died. Reference was given that the expected five-year survival for level IV melanoma is 32%. In the case of melanoma, 100% of deaths are caused by distant metastases. Reference was given that when metastases in many forms of solid malignant tumours are formed from the vascular network, the tumour cells moving in the blood circulation, at the beginning of metastasis formation, are attached to the vascular endothelium. Reference is also given that dipyridamole tends to prevent this attachment of cancer cells flowing in the blood circulation to the endothelium and thus tends to prevent the formation of metastases.

Dipyridamole, like aspirin, inhibits platelet adhesion, and thus tends to prevent the vascular thrombosis of heart attacks and strokes. In the Lancet in the December 12, 1987 issue (pp. 1,371-4) was the report of the European Stroke Prevention Study. The introduction to this report reviewed the indicated lack of benefit in treating with aspirin, patients who had survived a small stroke, a TIA, a temporary ischemic attack. In this trial, dipyridamole 300 mg a day was added to treatment with aspirin and the results were outstanding. Over a two-year period, stroke deaths were decreased by 50%, deaths from myocardial infarction decreased by 38% and deaths from cancer by 25%. The numbers of patients involved were small; however here is another indication of an anti-cancer effect of dipyridamole.

Dipyridamole is a harmless drug. The generic form of it costs less than one dollar a day for treatment. It has in one small trial been demonstrated that it is effective against melanoma. There is every reason to feel that it may be effective against a broad spectrum of cancers.

If it were granted that all cancer patients are at a greater risk of heart attacks and strokes, it is hoped that many doctors will treat cancer patients with dipyridamole for this reason. However if they do so, it will soon be found that dipyridamole will be having a marked anti-cancer effect.

Dipyridamole is prescribed by your GP. Professor Dalgliesh wrote to my GP and requested they prescribe it for me. It costs very little and does no harm and only good we hope!

As we hear of new drugs coming through clinical trials we will add them.

nf- P2X7
Biosceptre’s technology is based on the discovery of what potentially could be the world’s first truly universal cancer marker/target – a non-functional cellular receptor (nf-P2X7) that is found on cancer cells but is never present on healthy cells. This breakthrough has prompted the development of a patented range of monoclonal, polyclonal and domain antibodies that target diseased cells whilst having no adverse effect on surrounding healthy cells. The technology is unique in its ability to target all forms of tumours tested to date (both solid and blood based tumours) and has the potential to radically change the way cancer is diagnosed and treated in humans and other mammals.

Novel Marker nf-P2X7
P2X7 is a major cellular receptor responsible for normal programmed cell death (apoptosis). At the time an aging cell is ready to die, P2X7 is expressed on the cell wall triggering a sequence of biological processes that leads to apoptosis. This process is so fast that, under normal circumstances, P2X7 cannot be detected on the cell wall.
Cancer cells have abnormal “death receptors” (nf-P2X7) on their surface and programmed cell death (apoptosis) does not occur. Biosceptre’s custom-made antibodies attach themselves to these abnormal receptors and this combination then appears to result in death of the cancer cells – perhaps by re-initiation of normal apoptosis, perhaps by another mechanism such as attracting lymphocytes and macrophages which are involved in killing cells. This is depicted in the figure below:

Universal Cancer Marker
Historically, the cancer markers discovered by researchers have usually been specific to only one or two forms of cancer. Through rigorous testing, Biosceptre has already confirmed the presence of nf-P2X7 in cancers of the prostate, breast, bowel, oesophagus, skin, lung, cervix, uterus, lymph nodes, ovaries, brain, stomach, bladder and other organs. These historic findings have been independently verified.
nf-P2X7 is highly specific and has been found in all cancers tested to date, providing an unprecedented, universal cancer marker and therapeutic target.

Hedgehog signalling pathway
While it is already known that breast cancer cells create the conditions for their own survival by communicating their needs to the healthy cells that surround them, Australian researchers have identified a new way of turning off that cellular cross talk.

They have shown that a molecule known as ‘hedgehog’ sits at the centre of the switchboard in breast cancer, transmitting biochemical signals between the cancer cells and healthy cells. When this conversation is blocked – or hedgehog is ‘silenced’ – tumours shrink and stop their spread.

While the finding applies to all breast cancers, it is particularly relevant for women with basal (triple negative cancer) breast cancer, for which there is no current targeted therapy.

The good news is that drugs for silencing hedgehog are already undergoing Phase 2 clinical trials in other cancer types. Clinical Associate Professor Sandra O’Toole and Dr Alex Swarbrick, from Sydney’s Garvan Institute of Medical Research, analysed breast tumour samples from a cohort of 279 women with advanced breast cancer, revealing that the higher the level of hedgehog, the more aggressive the cancer.

Having discovered high levels of hedgehog in some breast cancer patients, they went on to over-produce the protein in mouse models of basal breast cancer. Mice developed tumours that grew and spread through the body rapidly. When hedgehog was blocked, the tumour growth and spread were significantly slowed.

Naltrexone

Naltrexone itself was approved by the FDA in 1984 in a 50mg dose for the purpose of helping heroin or opium addicts, by blocking the effect of such drugs. By blocking opioid receptors, naltrexone also blocks the reception of the opioid hormones that our brain and adrenal glands produce: beta-endorphin and metenkephalin. Many body tissues have receptors for these endorphins and enkephalins, including virtually every cell of the body’s immune system.

In 1985, Bernard Bihari, MD, a physician with a clinical practice in New York City, discovered the effects of a much smaller dose of naltrexone (approximately 3mg once a day) on the body’s immune system. He found that this low dose, taken at bedtime, was able to enhance a patient’s response to infection by HIV, the virus that causes AIDS.

In the mid-1990’s, Dr. Bihari found that patients in his practice with cancer (such as lymphoma or pancreatic cancer) could benefit, in some cases dramatically, from LDN.

How does LDN work? 

LDN boosts the immune system, activating the body’s own natural defences.

The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that is caused by taking LDN at bedtime each night is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production. Normal volunteers who have taken LDN in this fashion have been found to have much higher levels of beta-endorphins circulating in their blood in the following days.

In human cancer, research by Zagon over many years has demonstrated inhibition of a number of different human tumours in laboratory studies by using endorphins and low dose naltrexone. It is suggested that the increased endorphin and enkephalin levels, induced by LDN, work directly on the tumours’ opioid receptors — and, perhaps, induce cancer cell death (apoptosis). In addition, it is believed that they act to increase natural killer cells and other healthy immune defences against cancer.

In general, in people with diseases that are partially or largely triggered by a deficiency of endorphins (including cancer and autoimmune diseases), or are accelerated by a deficiency of endorphins (such as HIV/AIDS), restoration of the body’s normal production of endorphins is the major therapeutic action of LDN.

As of mid-2004, Dr. Bihari reported having treated over 300 patients who had a cancer that had failed to respond to standard treatments. Of that group, some 50%, after four to six months treatment with LDN, began to demonstrate a halt in cancer growth and, of those; over one-third have shown objective signs of tumour shrinkage.

How is it possible that one medication can impact such a wide range of disorders?

The disorders listed above all share a particular feature: in all of them, the immune system plays a central role. Low blood levels of endorphins are generally present, contributing to the disease-associated immune deficiencies.

Research by others — on neuropeptide receptors expressed by various human tumours — has found opioid receptors in many types of cancer:

  • Brain tumours (both astrocytoma and glioblastoma)
  • Breast cancer
  • Endometrial cancer
  • Head and neck squamous cell carcinoma
  • Myeloid leukaemia
  • Lung cancer (both small cell and non-small cell)
  • Neuroblastoma and others…

What dosage and frequency should my physician prescribe?

The usual adult dosage is 4.5mg taken once daily at night. Because of the rhythms of the body’s production of master hormones, LDN is best taken between 9pm and 3am. Most patients take it at bedtime.

Notable exceptions:

  • People who have multiple sclerosis that has led to muscle spasms are advised to use only 3mg daily and to maintain that dosage.

The therapeutic dosage range for LDN is from 1.5mg to 4.5mg every night. Dosages below this range are likely to have no effect at all, and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness.

LDN has virtually no side effects. Occasionally, during the first week’s use of LDN, patients may complain of some difficulty sleeping. This rarely persists after the first week. Should it do so, dosage can be reduced from 4.5mg to 3mg nightly.

For more information please go to: http://www.lowdosenaltrexone.org/index.htm#How_does_LDN_work_

I have been prescribed this by Dr Nesselhut who highly recommends this treatment. I had not heard of it until he mentioned it.

I bought naltrexone from a UK charity for a very reasonable price after having spoken to a doctor on the telephone there.
The details for the Low Dose Naltrexone trust is: http://www.ldnresearchtrust.org/
There is a lot of information on here and very worth reading.

Metformin – Can a Diabetes Drug Prevent Cancer Death?

With its near-perfect safety record, low cost, and favourable side-effect profile, the anti-diabetic drug metformin is one of the few FDA-approved drugs recommends its members should take every day.

Between 1990 and 2011 alone, 1 over 1,000 published studies have yielded confirmatory data on its numerous anti-aging properties, from weight loss and glucose control to cardiovascular disease and cancer defence.

As the medical establishment continues to ignore this mounting body of evidence, ongoing research powerfully validates our position.

In one of the largest studies of its kind, a team of scientists analyzed cancer risk among 8,000 diabetics treated with metformin.2 Over a 10-year period; they observed a 54% lower incidence of all cancers compared to the general population.

Metformin not only exerted a major protective effect against cancer development, but those who developed cancer exhibited a significantly higher survival rate, including those with malignant cancers of the lung, colon, and breast. Of equal significance was the finding that the earlier the metformin regimen was initiated, the greater the preventive benefit.

Given that diabetics are predisposed to a horrifically wide array of cancers—of the breast, colon, liver, pancreas, kidney, endometrium (uterine lining), among others3-5—these results have profound implications for all maturing individuals.

In this article, the most recent data supporting metformin’s anti-cancer mechanisms are detailed. You will learn of its specific mechanisms of action, which shed further light on the link between obesity, diabetes, and cancer initiation. You will also discover how metformin induces cancer cell death at their earliest stages of development via metabolic pathways that also promote weight loss and optimal glucose control.

Metformin Slashes Cancer Risk in Multiple Clinical Trials

The study cited in the introduction of this article (54% lower risk of cancer) was of such medical importance as to merit an accompanying editorial by noted cancer epidemiologist Bruce B. Duncan, MD, PhD.6 Duncan observed that this was the most compelling amongst a rapidly growing set of studies, all suggesting that metformin might induce profound effects in preventing a wide range of cancers while improving prognosis in people who do develop malignancies.6

Additional supportive studies validate these findings.6 In a cohort study of more than 12,000 patients, metformin users died of cancer 30% less often than those taking another category of drug called sulfonylureas (including DiaBeta® and Glucotrol®).6,7 Of equal and even greater significance, people taking insulin had a 90% greater death rate than the metformin users in that study.6

In a second study of different design, people taking metformin for diabetes control for more than 36 months had a 72% lower risk of developing cancer than those on other regimens.6, 8 Similarly, in a third study, metformin users had a 62% lower risk of developing cancer, compared with those who had never used metformin.6, 9 Of significance, that study also showed an increased risk of cancer in people who were taking insulin or oral ant diabetes drugs other than metformin.

There’s additional evidence that metformin not only prevents cancer from developing, but also helps to improve the prognosis in patients who do develop tumours. In one study of breast cancer patients on chemotherapy, 24% of those who were also taking metformin had a complete response rate, compared with just 8% for those not taking it.6,10 As a result of these “incidental” findings, scientists have initiated several clinical trials to examine the impact of metformin as formal additional treatment for breast and other cancers.6,11

Numerous recent studies further support a close association between metformin use and substantially reduced cancer incidence, along with improved survival.12-16

These observations raise the question, “Why should a diabetes drug protect against cancer?”6

The answer is both simple and surprising.

Diabesity and Cancer Initiation: How Metformin Works

Cancer Cell

Years of clinical analysis have confirmed the link between obesity and diabetes, conditions whose co-occurrence has given rise to the term diabesity.

Diabesity is a direct causative factor in the development of a wide range of cancers. Diabetics have as much as a 41% increased risk for virtually all cancer types compared to healthy people. Elevated blood sugar alone increases the risk of certain cancers, including those of the kidney, pancreas, and skin (melanoma).6,17,18

Obesity increases cancer risk for more than a dozen different cancers.6 A 59% increase in cancer risk has been documented for every 5-unit increase in body mass index (BMI) alone.6,19 Studies show that obesity is responsible for up to 20% of cancer deaths in women.20

The link between diabesity and cancer points to the underlying mechanisms of action by which metformin works as a cancer-preventing agent.

Metformin operates at the molecular level by activating adenosine monophosphate-activated protein kinase or AMPK, a molecule essential to life. AMPK or its molecular analogs are present in virtually all living organisms.6,21 It also happens to be intimately involved in cellular processes whose dysregulation play a central role in both diabesity and cancer initiation.

Diabetes and obesity result from various metabolic derangements. Cancer results from disordered regulation of cell growth. AMPK is critical to normal regulation of both metabolism and cell growth, as a result of millions of years of evolutionary development.6

As a fuel-sensor and metabolic master switch, AMPK recognizes and responds to changes in cellular energy levels, determining how fats and carbohydrates will be used in storing or utilizing energy.6 In metabolic terms, AMPK tells cells to conserve and generate new energy stores. In so doing, it lowers sugar output from the liver, increases glucose uptake from the blood, maintains insulin sensitivity, and ultimately lowers blood sugar.6,21

AMPK exerts similar effects in terms of regulating cell growth and replication, instructing cells to conserve energy, slowing and often shutting down aberrant cell growth entirely. In essence, when AMPK is activated, incipient cancer cells starve themselves to death for lack of adequate energy supplies.22

We can naturally activate AMPK in our bodies through several time-honoured mechanisms. Calorie restriction lowers cellular energy stores and activates AMPK.23 Known to increase life span in virtually all species, calorie restriction has been shown to reduce cancer incidence and death in primate studies.24,25 And a recent study showed that gastric bypass surgery not only produced sustained weight loss, but also reduced cancer incidence by 42% in women patients (no effect was seen in men).6,26

Exercise is another strong natural activator of AMPK, and studies show that people with the highest levels of physical activity are protected against cancers of the lung and colon by as much as 30%.6,27,28

Exercise and weight loss are lifestyle changes that most of us need to make, while bariatric surgery and massive calorie restriction have more limited appeal and application as means of activating AMPK and lowering cancer risk.

Metformin, a natural product of the French lilac, 29 is a safe, readily available, and inexpensive way to activate AMPK and starve cancer cells of their energy supplies.6, 30, 31 In doing so, metformin powerfully restores healthy regulation—both of metabolic factors and of those that regulate cell growth.

Let’s now examine how metformin halts incipient cancers by quelling abnormal cellular proliferation, one of the earliest steps in cancer development.

  • The anti-diabetic drug metformin was recently shown to slash risk of all cancers by 54% among 8,000 diabetics over a 10-year period.
  • Prognosis among those under study who developed cancer was also significantly improved, including cancers of the lung, colon, and breast.
  • Supportive epidemiological studies reveal that people taking metformin for glucose control have markedly reduced rates of cancer, despite the higher cancer risks imposed by diabetes and obesity.
  • Detailed molecular analyses are elucidating the mechanisms by which metformin prevents cancer.
  • Metformin works through a common mechanism to lower blood glucose and to reduce cancer risk, shedding new light on the intimate relationship between diabetes, obesity, and cancer.
  • Laboratory and clinical data now strongly suggest that metformin can prevent cancers of the colon, lung, and breast, even in non-diabetic individuals.

If you are concerned about lowering your cancer risk and improving your metabolic profile, ask your doctor about starting a metformin regimen at a dose of 250-500 mg twice a day.

Metformin’s Anti-Cancer Power Confirmed in Lab Studies

Healthy, normal people develop incipient cancer cells in their bodies daily; these cells are normally destroyed by a number of natural processes. When those processes break down, the cancer cells are free to proliferate and form a tumour. An ideal anti-cancer drug, then, would eliminate these altered, “precancerous” cells before they could replicate and become invasive and malignant.32

Even in their earliest stages, aggressive cancer cells are notoriously energy-hungry, burning calories at a frenetic rate as they grow out of control.33 For that reason, targeting cancer cell metabolism now stands at the forefront of cancer prevention research.34 With its potent ability to shut off the cellular energy pipeline by activating AMPK, metformin is showing its value in preventing or slowing a host of cancer types in laboratory studies.

The consequences of AMPK activation by metformin are numerous. Metformin, added to cultures of many different cancer cell types, blocks proliferation by “stalling” cells at one of several phases of the cell replication cycle, preventing them from reproducing.34-37 Metformin’s ability to starve cancer cells of energy also enhances the rate of cell death by the process known as apoptosis, one of the body’s natural means of cancer control.34, 38

Perhaps the most detailed picture of metformin’s ant proliferative actions comes from a 2011 study in France.38 Researchers there added metformin to melanoma skin cancer cells in culture, and monitored the effects. At 24 hours, metformin had starved the cancer cells to the point that their replicative cell cycle was arrested. By 72 hours, the cells underwent autophagy, a mechanism whereby starving cells literally “eat themselves” in a desperate attempt to survive. And by 96 hours, the cancer cells began dying off en masse by apoptosis.

Several additional ant proliferative mechanisms have recently been demonstrated for metformin in addition to its effects on the AMPK energy-sensing pathway.35, 39-42 that ability to act by multiple mechanisms is called pleiotropy. It is powerfully beneficial because it prevents development of resistance to any one pathway. Pleiotropy is seen much more commonly with natural products such as metformin than with mono-targeted pharmaceutical drugs.

The combined effect of all of metformin’s pleiotropic mechanisms is a marked reduction of tumour growth in lab animals implanted with human cancer cells.36,43 To date, metformin-induced ant proliferative effects have been demonstrated in cancers of the brain, lung, breast, ovary, prostate, and colon.35-38,44-47 And human studies are now showing important reductions in various tumour markers when metformin is provided to breast cancer patients prior to tumour surgery.48 Importantly, in breast cancer cells, metformin is most active against cancer strains that are resistant to standard chemotherapy drugs.46

Using metformin may increase the risk of lactic acidosis, a rare but potentially fatal build-up of lactic acid in the blood. Since congestive heart failure, kidney impairment, and liver problems increase the risk of lactic acidosis, individuals with these conditions are advised against using metformin. Individuals with type 1 diabetes should not take the drug. People who have recently suffered a heart attack or stroke and those who have recently undergone surgery or are severely dehydrated are more vulnerable to lactic acidosis.63-65 Consult with your doctor if any of these conditions applies to you or if you are pregnant, planning to become pregnant, or breastfeeding.

Lactic acidosis is a medical emergency. Its symptoms include muscle pain, difficulty breathing, sleepiness, feeling extremely weak or tired, and abdominal pain with nausea, vomiting, or diarrhea.63-65 If you believe you are suffering from lactic acidosis, seek medical attention immediately.

Metformin Prevents Cancers in Non-Diabetic Individuals

Perhaps the most exciting news to come out of the recent surge in interest in metformin is that the drug can prevent cancers from forming in animals and humans who are not diabetic. As a “mimicker” of a calorie-restricted state, that might be expected of metformin, given that calorie restriction is such a potent cancer-preventive strategy.33, 49-51

Since 2008, a small explosion of studies has appeared demonstrating how effective metformin can be in this context, ultimately suggesting that it should be taken regularly by anyone who wants to reduce their risk of dying from cancer.

Research now demonstrates that metformin, provided orally to lab animals, prevents deadly colorectal cancers52 (the second leading cause of cancer deaths in the US, and an astonishingly preventable disease).53 Metformin suppresses intestinal polyp growth, a precursor of colorectal cancer, in mice predisposed to that disease.54 And, in a study of chemically induced colon cancer, metformin significantly reduced formation of so-called “aberrant crypt foci,” which in humans represent an early stage in cancer development.55

Those studies led to the first human study of metformin as a cancer preventive agent in non-diabetic people. Researchers studied 26 non-diabetic people with aberrant crypt foci that had been found on routine colonoscopy.56 They randomly assigned them to receive metformin 250 mg per day, or no treatment, and then performed repeat colonoscopy one month later. The metformin group had a significant decrease in the number of aberrant crypt foci, from nearly 9 per patient down to about 5 per patient, while control patients had no change. This represents a 55% reduction in this cancer precursor in patients taking low-dose metformin.

Chemoprevention studies now also demonstrate similar effects in other cancers. Mice supplemented with oral metformin, exposed to a potent tobacco carcinogen, developed 53% fewer lung cancers than did control animals.57 And when metformin was administered by injection, that protection rate rose to 72%.

Breast cancer prevention would represent a huge forward stride in extending human life span and reducing suffering. There’s encouraging data here as well. Mice given metformin in their drinking water for 13 days prior to injection with a powerful breast carcinogen had significantly delayed onset of tumour development.58 Several other studies have demonstrated that metformin-supplemented mice experience a reduction in proliferation of cancer-prone breast cells and inhibition of tumour growth.31

There is now a tremendous body of literature showing that metformin prevents cancer cells from proliferating, and moreover it prevents clinically relevant human cancers from developing, even in non-diabetic, non-obese individuals.59 As a result, one might expect to see large clinical trials of metformin in healthy older adults as a cancer chemo preventive agent.

Sadly, even though calls for such studies are gathering strength, to date no trial has been designed, let alone implemented.60-62 Given metformin’s impressive safety record over nearly 50 years of clinical use, 43 there is simply no reason for sensible people to wait for an “official” medical establishment recommendation. People who are concerned about their growing risk of cancer should simply speak to their physicians now, and present them with a synopsis of the data, so that they can begin potentially lifesaving use of metformin today.

The anti-diabetic drug metformin was recently shown to slash risk of all cancers by 54% among 8,000 diabetics over a 10-year period while significantly improving prognosis among those who developed cancer, including cancers of the lung, colon, and breast.

Diabetes and obesity are twin risks for cancer development. Metformin offers powerful protection against cancer in those populations. Aggressive scientific research is revealing that metformin’s action, activating the cellular energy sensor AMPK, is the key to both its metabolic benefits and its cancer chemo preventive capabilities.

Both human and animal studies definitively confirm that metformin lowers cancer risk dramatically while also preventing new cancer formation, in both diabetic and non-diabetic individuals. Metformin’s 50-year safety record, coupled with its low cost and favourable side effect profile, provide an ironclad rationale for most aging humans to consider taking metformin.

 

 

Blue Scorpion Venom

We heard of this through some news reports that Fidel Castro who has been living with stomach cancer for many years and is surviving well, has been using scorpion venom.

Through researching it we set it aside then one day when visiting Dr Nesselhut in Germany he mentioned the venom because one of his patients had great results in a short period of time. He believes that the scorpion venom boosts the T-cells and helps boost the immunity.

Well I had to have some!

It isn’t any old scorpion venom that can be used though. It derives from the blue scorpion found in the Caribbean.

So how does it work?

Evidence points to several possibilities, including that different chemicals in blue scorpion serum may work together to improve the body’s ability to fight cancer.

  • Triggering the body’s natural ability to kill cancer cells through a process of cellular suicide called apoptosis.
  • Starvation of cancer cells by causing cellular gates on cancer cells to close. With these gates in their cell walls closed, cancer cells cannot receive nutrition and weaken.
  • Improvement in t-cell response. T-cells are the body’s primary killers of cancer cells.
  • Affecting the transfer of neurological information in such a way to slow cancer growth.

The only product available is called Escozine which is currently made in Cuba.

Escozine® is a natural product which contains serum derived from the Caribbean blue scorpion. Over the last 15 years, countless thousands suffering from various cancers and immune-system related diseases have seen their health significantly improved through the use of blue scorpion serum.

I have been advised to take 1ml of liquid under the tongue, four times a day. When dropped under the tongue you are advised to hold it there for five minutes.

I do not propose for it to replace treatment but to it is an addition to treatment.
There are no side effects and the venom is contained within distilled water.

For more information on the product please visit: http://medolife.com/en/

 

 

GcMAF

What is GcMAF and how can it help you?

GcMAF (Gc Macrophage Activating Factor) is a natural protein that all healthy people naturally have inside of them. It is an immune system modulator that works by stimulating the activity of macrophages. Macrophages engulf and digest cellular debris as well as stimulate immune cells to respond to pathogens. However viruses and malignant cells like cancer release an enzyme known as Nagalase that defuse your GcMAF so that the macrophages cannot do their job and the immune system remains compromised.

Research into GcMAF has been occurring since 1990 and dozens of research papers have explored the role of extracted and purified GcMAF for a variety of conditions. Researchers and practitioners have demonstrated that GcMAF can reverse diseases that attack the immune system such as: chronic inflammation, bacterial and viral infections, chronic herpes, chronic acne, Lyme disease, fibromyalgia osteoporosis, Hodgkin’s, Lupus, MS, Parkinson’s and remarkably – autism.

What are Macrophages?

Macrophages are important cells of the immune system that are formed in response to an infection or accumulating damaged or dead cells. Macrophages are large, specialized cells that recognise, engulf and destroy target cells. The term macrophage is formed by the combination of the Greek terms “makro” meaning big and “phagein” meaning eat.

Vitamin D, proper nutrition and GcMAF

Vitamin D is needed to have the GcMAF work at its full potential. Some testing has shown that GcMAF works 2 ½ times faster in the presence of vitamin D. Making sure your vitamin D is at an optimum level will help maximize the impact of GcMAF. 80% of cancer patients have low levels of vitamin D.

A healthy diet that is full of lean meats and vegetables is advised during this treatment. Sugar should be avoided as well as most carbohydrates. Following a ‘caveman’ diet is shown to bring the highest impact of GcMAF during treatment they say.

Testing of Nagalase to Determine if GcMAF Should Be Considered

Since viruses and diseased cells release nagalase, people who have a higher level of nagalase in their body means that the immune system is not effective at dealing with invaders. Children with autism typically have nagalase levels triple the normal level.

Nagalase blood tests are available so that the number can be monitored to see the impact the GcMAF is having on the immune system. Typically if the number of nagalase in the blood is elevated, this means that GcMAF is needed to assist the immune system to get back into balance. People with normal nagalase levels typically will not benefit from GcMAF, so it is wise to get a blood test before treatment as well as periodically while on GcMAF. According to research, nagalase levels can be cut in half every eight weeks while on GcMAF.

Currently GcMAF can be used in a number of ways such as Bravo probiotic yoghurt, by intramuscular injections and via a nebuliser. It is possible to purchase the product online but it is recommended to visit their clinic in Switzerland.

I have personally been to their clinic and it is essentially a château being attended by many patients who are looking for alternatives or are very advanced.

GcMAF has a lot of speculation and their website makes bold claims. I would always recommend making your assumptions and doing your own research.

GcMAF Clinic

I was met by scientists and radiologists who are very passionate about their work, which began the week by doing ultrasound scans of my whole body. This was to establish any tumours and the state of my thyroid. They believe the thyroid affects the immune system. Hopefully they will be able to see your tumour and measure it. The hope is within your week there that the tumour will reduce by 25% or they will refund your money. Unfortunately if like me the tumours are in the lungs then this is not possible to give such measurements.

During the week, the appointments are approximately an hour long and there is a lecture once during the week. They advice on nutrition and supplements too.

I would recommend looking into GcMAF by going to their website:

www.gcmaf.eu

The cost of the week treatment is currently 3000 Euros. Hotels are nearby and there is plenty to do whilst wiling the week away.
There have been many developments to GcMAF since I went and had treatment. You may now find it difficult to have onsite treatment. Please search on the internet for more information.

RGCC Blood Testing

Cancer doctors principally rely on the statistical analysis of large treatment trials, to decide which drugs to use for specific cancers. There is a growing interest, however, in personalised cancer therapy, which involves identifying those treatments which may work best for an individual’s cancer. Chemosensitivity testing is one method of doing this.

Chemosensitivity testing involves testing an individual’s cancer cells in the laboratory to see which drugs demonstrate the best response. It therefore provides guidance about which treatments may be best for the individual in clinical practice.

The RGCC test is a blood test (or sometimes tissue). Tumour cells are identified and isolated from the sample for the following analysis:

  • Viability testing of chemotherapy drugs
  • Genetic profiling for guidance about targeted therapies eg; monoclonal antibodies
  • Viability testing (and identification of mechanisms of action) of natural substances which may be used as part of a complementary treatment strategy .

The results are presented in a written report which your doctor can use to help guide your treatment options and choices.

Who are these tests for?

  • People who want to actively engage in reducing their risk of developing cancer in the future
  • People with an increased risk of cancer e.g. due to family history or lifestyle/environmental issues who want the opportunity to engage in a screening programme for early detection and diagnosis.
  • People with a current diagnosis of cancer who want more information about treatment options for them as an individual – including natural treatments.

What are circulating tumour cells?

CTC’s are breakaway cells from a primary cancer site which enter the blood stream and can circulate with the potential to spread the disease to distant organs. These cells can be isolated and identified, and there is growing interest in their detection for the following purposes:

  • The early detection and diagnosis of new cancers
  • Monitoring of existing cancers
  • Prognosis – providing information about the risk of recurrence of a current or old cancer

The tests can also show what complementary treatments may work too such as naltrexone, Curcumin, vitamin C and so on.

The cost is currently in the region of £2000.

Contact details

RGCC-Europe N&W Ltd
Litfield House Medical Centre
1 Litfield Place
Clifton
Bristol
BS8 3LS
United Kingdom
T: +44 (0)117 317 1460
E: info@rgcc-europe-nw.com
W: www.rgcc-europe-nw.com

TACE (Trans Arterial Chemo Embolisation)
This is a treatment that is currently unavailable to people like me in the UK but could be available to those who have liver mets. Although I don’t want to have chemotherapy of any kind I am aware that combining treatments such immunotherapy with conventional treatments such as chemo and radiotherapy is highly effective. Therefore I was attracted to having TACE because it is less invasive in many ways compared to chemo that is infused intravenously every three weeks.

What is TACE?
TACE is an image-guided, non-surgical procedure that is used to treat malignant lesions in organs such as the liver and lungs. The procedure uses a catheter to deliver both chemotherapy medication and embolization materials into the blood vessels that lead to the tumour. This allows doctors to treat tumours that are not accessible using conventional surgery or radiation treatments.
The procedure is straight forward. A local anaesthetic is given and then a small knick in the groin allows a very small tube to be inserted into the lung where the chemo drugs are pumped directly at the tumour/activity area. This process takes less than fifteen minutes.
Recovery is about four hours in a ward lying flat, followed by a CT scan to see if there is any internal bleeding or complications. All being well, you are able to leave hospital.
I have probably had about ten TACE’s, and apart from feeling slightly unwell for a day or so, there are no other side effects such as mouth ulcers etc.
Professor Vogl used gemcitabine and cisplatin on me and it continued to have a positive effect by reducing the tumour size every time I had it. The cost is approximately 4000 euros each TACE.